In this wide-ranging interview, Bob Jessop discusses the development of, and many of the main themes in, his work over the last fifty years. He explains how he became interested in realism and Marxism; and he describes the various influences on his highly influential theory of the state. The discussion explores his strategic-relational approach, his thoughts on regulation theory, variegated capitalism, post-disciplinarity, cultural political economy and his ‘spatial-turn’, as well as neoliberalism, contemporary events and looming problems of climate change and crisis.