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The tylosin-biosynthetic genes of Streptomyces fradiae

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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The tylosin-biosynthetic genes of Streptomyces fradiae. / Cundliffe, Eric; Bate, Neil; Butler, Andrew et al.
In: Antonie van Leeuwenhoek, Vol. 79, No. 3-4, 09.2001, p. 229-234.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Cundliffe, E, Bate, N, Butler, A & Fish, SA 2001, 'The tylosin-biosynthetic genes of Streptomyces fradiae', Antonie van Leeuwenhoek, vol. 79, no. 3-4, pp. 229-234. https://doi.org/10.1023/A:1012065300116

APA

Cundliffe, E., Bate, N., Butler, A., & Fish, S. A. (2001). The tylosin-biosynthetic genes of Streptomyces fradiae. Antonie van Leeuwenhoek, 79(3-4), 229-234. https://doi.org/10.1023/A:1012065300116

Vancouver

Cundliffe E, Bate N, Butler A, Fish SA. The tylosin-biosynthetic genes of Streptomyces fradiae. Antonie van Leeuwenhoek. 2001 Sept;79(3-4):229-234. doi: 10.1023/A:1012065300116

Author

Cundliffe, Eric ; Bate, Neil ; Butler, Andrew et al. / The tylosin-biosynthetic genes of Streptomyces fradiae. In: Antonie van Leeuwenhoek. 2001 ; Vol. 79, No. 3-4. pp. 229-234.

Bibtex

@article{ec2f610b0f72440b9ea7eb97ca3b78d9,
title = "The tylosin-biosynthetic genes of Streptomyces fradiae",
abstract = "The tylosin-biosynthetic (tyl) gene cluster occupies about 1% of the genome of Streptomyces fradiae and includes at least 43 open reading frames. In addition to structural genes required for tylosin production, the tyl cluster contains three resistance determinants and several regulatory genes. Tylosin production is evidently controlled by pathway-specific and pleiotropic regulators with the likely involvement of gamma -butyrolactone signalling factors. Accumulation of the polyketide aglycone is controlled by glycosylated macrolides and optimal performance of the complex polyketide synthase enzyme requires the activity of an editing thioesterase.",
keywords = "deoxyhexose , γ-butyrolactone, macrolide , polyketide editing , Streptomyces , thioesterase, tylosin",
author = "Eric Cundliffe and Neil Bate and Andrew Butler and Fish, {Steven Anthony}",
year = "2001",
month = sep,
doi = "10.1023/A:1012065300116",
language = "English",
volume = "79",
pages = "229--234",
journal = "Antonie van Leeuwenhoek",
issn = "0003-6072",
publisher = "Springer Netherlands",
number = "3-4",

}

RIS

TY - JOUR

T1 - The tylosin-biosynthetic genes of Streptomyces fradiae

AU - Cundliffe, Eric

AU - Bate, Neil

AU - Butler, Andrew

AU - Fish, Steven Anthony

PY - 2001/9

Y1 - 2001/9

N2 - The tylosin-biosynthetic (tyl) gene cluster occupies about 1% of the genome of Streptomyces fradiae and includes at least 43 open reading frames. In addition to structural genes required for tylosin production, the tyl cluster contains three resistance determinants and several regulatory genes. Tylosin production is evidently controlled by pathway-specific and pleiotropic regulators with the likely involvement of gamma -butyrolactone signalling factors. Accumulation of the polyketide aglycone is controlled by glycosylated macrolides and optimal performance of the complex polyketide synthase enzyme requires the activity of an editing thioesterase.

AB - The tylosin-biosynthetic (tyl) gene cluster occupies about 1% of the genome of Streptomyces fradiae and includes at least 43 open reading frames. In addition to structural genes required for tylosin production, the tyl cluster contains three resistance determinants and several regulatory genes. Tylosin production is evidently controlled by pathway-specific and pleiotropic regulators with the likely involvement of gamma -butyrolactone signalling factors. Accumulation of the polyketide aglycone is controlled by glycosylated macrolides and optimal performance of the complex polyketide synthase enzyme requires the activity of an editing thioesterase.

KW - deoxyhexose

KW - γ-butyrolactone

KW - macrolide

KW - polyketide editing

KW - Streptomyces

KW - thioesterase

KW - tylosin

U2 - 10.1023/A:1012065300116

DO - 10.1023/A:1012065300116

M3 - Journal article

VL - 79

SP - 229

EP - 234

JO - Antonie van Leeuwenhoek

JF - Antonie van Leeuwenhoek

SN - 0003-6072

IS - 3-4

ER -