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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Therapeutic potential of flavonoids in spinal cord injury
AU - Zhang, Peng
AU - Holscher, Christian
AU - Ma, Xun
N1 - ©2017 Walter de Gruyter GmbH, Berlin/Boston.
PY - 2017/1
Y1 - 2017/1
N2 - Spinal cord injury (SCI) is a catastrophic event that can profoundly affect a patient's life, with far-reaching social and economic effects. A consequential sequence of SCI is the significant neurological or psychological deficit, which obviously contributes to the overall burden of this condition. To date, there is no effective treatment for SCI. Therefore, developing novel therapeutic strategies for SCI is highly prioritized. Flavonoids, one of the most numerous and ubiquitous groups of plant metabolites, are the active ingredients of traditional Chinese medicine such as Scutellaria baicalensis Georgi (Huang Qin) or Ginkgo biloba (Ying Xin). Accumulated research data show that flavonoids possess a range of key pharmacological properties such as anti-inflammatory, anti-oxidant, anti-tumor, anti-viral, anti-cardiovascular disease, immunomodulatory, and neuroprotective effects. Based on this, the flavonoids show therapeutic potential for SCI diseases. In this paper, we will review the pharmacological properties of different types of flavonoids for the treatment of SCI diseases, and potential underlying biochemical mechanisms of action will also be described.
AB - Spinal cord injury (SCI) is a catastrophic event that can profoundly affect a patient's life, with far-reaching social and economic effects. A consequential sequence of SCI is the significant neurological or psychological deficit, which obviously contributes to the overall burden of this condition. To date, there is no effective treatment for SCI. Therefore, developing novel therapeutic strategies for SCI is highly prioritized. Flavonoids, one of the most numerous and ubiquitous groups of plant metabolites, are the active ingredients of traditional Chinese medicine such as Scutellaria baicalensis Georgi (Huang Qin) or Ginkgo biloba (Ying Xin). Accumulated research data show that flavonoids possess a range of key pharmacological properties such as anti-inflammatory, anti-oxidant, anti-tumor, anti-viral, anti-cardiovascular disease, immunomodulatory, and neuroprotective effects. Based on this, the flavonoids show therapeutic potential for SCI diseases. In this paper, we will review the pharmacological properties of different types of flavonoids for the treatment of SCI diseases, and potential underlying biochemical mechanisms of action will also be described.
KW - anti-apoptosis
KW - anti-inflammatory
KW - anti-oxidants
KW - flavonoids
KW - neuroprotection
KW - pharmacology
KW - spinal cord injury
KW - HYDROXYSAFFLOR YELLOW-A
KW - MESENCHYMAL STEM-CELLS
KW - SCUTELLARIA-BAICALENSIS-GEORGI
KW - CEREBRAL-ARTERY OCCLUSION
KW - OXIDATIVE STRESS
KW - FUNCTIONAL RECOVERY
KW - GINKGO-BILOBA
KW - EPIGALLOCATECHIN GALLATE
KW - LIPID-PEROXIDATION
KW - ANIMAL-MODEL
U2 - 10.1515/revneuro-2016-0053
DO - 10.1515/revneuro-2016-0053
M3 - Journal article
VL - 28
SP - 87
EP - 101
JO - Reviews in the Neurosciences
JF - Reviews in the Neurosciences
SN - 0334-1763
IS - 1
ER -