Home > Research > Publications & Outputs > Thyroxin releasing chitosan/collagen based smar...

Associated organisational unit

Links

Text available via DOI:

View graph of relations

Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published

Standard

Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization. / Aleem, Abdur Raheem; Shahzadi, Lubna; Alvi, Farah; Khan, Ather Farooq; Chaudhry, Aqif Anwar; Rehman, Ihtesham Ur; Yar, Muhammad.

In: Materials and Design, Vol. 133, 05.11.2017, p. 416-425.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Aleem, AR, Shahzadi, L, Alvi, F, Khan, AF, Chaudhry, AA, Rehman, IU & Yar, M 2017, 'Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization', Materials and Design, vol. 133, pp. 416-425. https://doi.org/10.1016/j.matdes.2017.07.053

APA

Aleem, A. R., Shahzadi, L., Alvi, F., Khan, A. F., Chaudhry, A. A., Rehman, I. U., & Yar, M. (2017). Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization. Materials and Design, 133, 416-425. https://doi.org/10.1016/j.matdes.2017.07.053

Vancouver

Aleem AR, Shahzadi L, Alvi F, Khan AF, Chaudhry AA, Rehman IU et al. Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization. Materials and Design. 2017 Nov 5;133:416-425. https://doi.org/10.1016/j.matdes.2017.07.053

Author

Aleem, Abdur Raheem ; Shahzadi, Lubna ; Alvi, Farah ; Khan, Ather Farooq ; Chaudhry, Aqif Anwar ; Rehman, Ihtesham Ur ; Yar, Muhammad. / Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization. In: Materials and Design. 2017 ; Vol. 133. pp. 416-425.

Bibtex

@article{f557b867753b45fb8a76b2dae2b4ac27,
title = "Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization",
abstract = "The development of new biomaterials with tailored properties is highly desired in tissue engineering field. The neovascularization is essential part of tissue regeneration which provides food and nutrients to cells. There is a real need for proangiogenic biomaterials to assist wound healing. The ideal dressing should be inexpensive and achieve rapid healing with minimal inconvenience to the patient. In this paper, new porous thyroxin containing pro-angiogenic hydrogels were generated via freeze gelation protocol. The chemical structural analysis of the synthesized hydrogels was investigated by Fourier Transform Infrared (FTIR) spectroscopy. The morphology and pore dimensions were studied by scanning electron microscopy (SEM). In swelling studies, 10 μg thyroxine loaded hydrogel (TLH-10) showed greater degree of swelling as compared to 1 μg loaded thyroxine material (TLH-1) and control. The degradation studies were tested in three different media, i.e. phosphate buffer saline (PBS), lysozyme and hydrogen peroxide and relatively higher degradation was seen in hydrogen peroxide. The synthesized materials were implanted on the chick chorioallantoic membrane to investigate their angiogenic potential. The TLH-1 hydrogel stimulated angiogenesis greater than the TLH-10; in this case blood vessels were attached and very much grown into the scaffold.",
keywords = "Thyroxine, CAM-assay, Chitosan, Collagen, Biodegradable, Tissue engineering, Angiogenesis",
author = "Aleem, {Abdur Raheem} and Lubna Shahzadi and Farah Alvi and Khan, {Ather Farooq} and Chaudhry, {Aqif Anwar} and Rehman, {Ihtesham Ur} and Muhammad Yar",
year = "2017",
month = nov,
day = "5",
doi = "10.1016/j.matdes.2017.07.053",
language = "English",
volume = "133",
pages = "416--425",
journal = "Materials and Design",
issn = "0261-3069",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization

AU - Aleem, Abdur Raheem

AU - Shahzadi, Lubna

AU - Alvi, Farah

AU - Khan, Ather Farooq

AU - Chaudhry, Aqif Anwar

AU - Rehman, Ihtesham Ur

AU - Yar, Muhammad

PY - 2017/11/5

Y1 - 2017/11/5

N2 - The development of new biomaterials with tailored properties is highly desired in tissue engineering field. The neovascularization is essential part of tissue regeneration which provides food and nutrients to cells. There is a real need for proangiogenic biomaterials to assist wound healing. The ideal dressing should be inexpensive and achieve rapid healing with minimal inconvenience to the patient. In this paper, new porous thyroxin containing pro-angiogenic hydrogels were generated via freeze gelation protocol. The chemical structural analysis of the synthesized hydrogels was investigated by Fourier Transform Infrared (FTIR) spectroscopy. The morphology and pore dimensions were studied by scanning electron microscopy (SEM). In swelling studies, 10 μg thyroxine loaded hydrogel (TLH-10) showed greater degree of swelling as compared to 1 μg loaded thyroxine material (TLH-1) and control. The degradation studies were tested in three different media, i.e. phosphate buffer saline (PBS), lysozyme and hydrogen peroxide and relatively higher degradation was seen in hydrogen peroxide. The synthesized materials were implanted on the chick chorioallantoic membrane to investigate their angiogenic potential. The TLH-1 hydrogel stimulated angiogenesis greater than the TLH-10; in this case blood vessels were attached and very much grown into the scaffold.

AB - The development of new biomaterials with tailored properties is highly desired in tissue engineering field. The neovascularization is essential part of tissue regeneration which provides food and nutrients to cells. There is a real need for proangiogenic biomaterials to assist wound healing. The ideal dressing should be inexpensive and achieve rapid healing with minimal inconvenience to the patient. In this paper, new porous thyroxin containing pro-angiogenic hydrogels were generated via freeze gelation protocol. The chemical structural analysis of the synthesized hydrogels was investigated by Fourier Transform Infrared (FTIR) spectroscopy. The morphology and pore dimensions were studied by scanning electron microscopy (SEM). In swelling studies, 10 μg thyroxine loaded hydrogel (TLH-10) showed greater degree of swelling as compared to 1 μg loaded thyroxine material (TLH-1) and control. The degradation studies were tested in three different media, i.e. phosphate buffer saline (PBS), lysozyme and hydrogen peroxide and relatively higher degradation was seen in hydrogen peroxide. The synthesized materials were implanted on the chick chorioallantoic membrane to investigate their angiogenic potential. The TLH-1 hydrogel stimulated angiogenesis greater than the TLH-10; in this case blood vessels were attached and very much grown into the scaffold.

KW - Thyroxine

KW - CAM-assay

KW - Chitosan

KW - Collagen

KW - Biodegradable

KW - Tissue engineering

KW - Angiogenesis

U2 - 10.1016/j.matdes.2017.07.053

DO - 10.1016/j.matdes.2017.07.053

M3 - Journal article

VL - 133

SP - 416

EP - 425

JO - Materials and Design

JF - Materials and Design

SN - 0261-3069

ER -