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Thyroxine impregnated chitosan-based dressings stimulate angiogenesis and support fast wounds healing in rats: Potential clinical candidates

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • L. Shahzadi
  • M. Bashir
  • S. Tehseen
  • M. Zehra
  • A. Mehmood
  • A.A. Chaudhry
  • I.U. Rehman
  • M. Yar
<mark>Journal publication date</mark>1/10/2020
<mark>Journal</mark>International Journal of Biological Macromolecules
Number of pages11
Pages (from-to)296-306
Publication StatusPublished
Early online date19/05/20
<mark>Original language</mark>English


This research paper demonstrates efficacy of chitosan and thyroxine loaded chitosan (CS) dressings for their angiogenic and wound healing potential. The dressings were prepared by freeze gelation method. Thyroxine was loaded by physical adsorption into chitosan membranes. The porosity was analyzed by scanning electron microscopy (SEM) and chemical structures were investigated by Fourier transform infra-red spectroscopy (FTIR). Cell culture studies showed materials were non-toxic and chorioallantoic membranes assay (CAM) confirmed that the thyroxine loaded chitosan stimulated angiogenesis much higher than simple chitosan dressings. In addition, thyroxine loaded dressings showed excellent wound healing potential when tested on full thickness rats wounds. A good epithelialization was obtained along with robust wound closure. Overall, as compared to chitosan, thyroxine containing membranes showed high level of angiogenesis and fast wound healing.