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Towards a platform model of the IL-1 stimulated NF-kB signalling pathway using communicating stream X-machines

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Towards a platform model of the IL-1 stimulated NF-kB signalling pathway using communicating stream X-machines. / Williams, Richard Alun; Timmis, Jon; Qwarnstrom, Eva E.

CosMoS 2015: Proceedings of the 2015 Workshop on Comlex Systems Modelling and Simulation. ed. / Susan Stepney; Paul S. Andrews. Frome : Luniver Press, 2015. p. 107-110.

Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNConference contribution/Paperpeer-review

Harvard

Williams, RA, Timmis, J & Qwarnstrom, EE 2015, Towards a platform model of the IL-1 stimulated NF-kB signalling pathway using communicating stream X-machines. in S Stepney & PS Andrews (eds), CosMoS 2015: Proceedings of the 2015 Workshop on Comlex Systems Modelling and Simulation. Luniver Press, Frome, pp. 107-110, 8th Workshop on Complex Systems Modelling and Simulation, York, United Kingdom, 20/07/15. <http://www.cosmos-research.org/docs/cosmos2015-proceedings.pdf>

APA

Williams, R. A., Timmis, J., & Qwarnstrom, E. E. (2015). Towards a platform model of the IL-1 stimulated NF-kB signalling pathway using communicating stream X-machines. In S. Stepney, & P. S. Andrews (Eds.), CosMoS 2015: Proceedings of the 2015 Workshop on Comlex Systems Modelling and Simulation (pp. 107-110). Luniver Press. http://www.cosmos-research.org/docs/cosmos2015-proceedings.pdf

Vancouver

Williams RA, Timmis J, Qwarnstrom EE. Towards a platform model of the IL-1 stimulated NF-kB signalling pathway using communicating stream X-machines. In Stepney S, Andrews PS, editors, CosMoS 2015: Proceedings of the 2015 Workshop on Comlex Systems Modelling and Simulation. Frome: Luniver Press. 2015. p. 107-110

Author

Williams, Richard Alun ; Timmis, Jon ; Qwarnstrom, Eva E. / Towards a platform model of the IL-1 stimulated NF-kB signalling pathway using communicating stream X-machines. CosMoS 2015: Proceedings of the 2015 Workshop on Comlex Systems Modelling and Simulation. editor / Susan Stepney ; Paul S. Andrews. Frome : Luniver Press, 2015. pp. 107-110

Bibtex

@inproceedings{d47b7fd46a3c4aa29a5a7d9c263c6c96,
title = "Towards a platform model of the IL-1 stimulated NF-kB signalling pathway using communicating stream X-machines",
abstract = "The Nuclear Factor-kappa B (NF-κB) signalling pathway is one of the key signalling pathways involved in the control and regulation of the immune system [3]. Activation of the NF-κB transcription factor is a tightly regulated event, with NF-κB normally sequestered in the cytosol of non-stimulated cells. Following activation of a cell membrane receptor and propagation of the signal via intracellular signalling to the IκB Kinase (IKK), phosphorylation-induced degradation of IκB inhibitors occurs to facilitate the release of NF-κB and its translocation to the nucleus. Dysregulation of the pathway is known to be involved in a large number of inflammatory diseases.Although considerable research has been performed since its discovery in 1986, we are still not in a position to control the signalling pathway, and thus limit the effects of NF-κB within promotion of inflammatory diseases. Through adherence to the CoSMoS framework, we are developing a computational model of the IL-1 stimulated NF-κB intracellular signalling pathway, to assist in promoting our understanding of the mechanistic behaviours within the signalling network, and therefore identify potential targets for therapeutic interventions. We have previously developed a separate domain model [4, 5] as advocated by the CoSMoS framework, which captures the essential processes and entities of the system under study using; in particular, the emergent behaviour, at an appropriate level of abstraction using a mixture of cartoon and UML diagrams, along with statistical techniques to define the temporal-spatial dynamics.",
author = "Williams, {Richard Alun} and Jon Timmis and Qwarnstrom, {Eva E.}",
year = "2015",
month = jul,
day = "20",
language = "English",
isbn = "9781905986460",
pages = "107--110",
editor = "Susan Stepney and Andrews, {Paul S. }",
booktitle = "CosMoS 2015",
publisher = "Luniver Press",
note = "8th Workshop on Complex Systems Modelling and Simulation ; Conference date: 20-07-2015 Through 20-07-2015",

}

RIS

TY - GEN

T1 - Towards a platform model of the IL-1 stimulated NF-kB signalling pathway using communicating stream X-machines

AU - Williams, Richard Alun

AU - Timmis, Jon

AU - Qwarnstrom, Eva E.

PY - 2015/7/20

Y1 - 2015/7/20

N2 - The Nuclear Factor-kappa B (NF-κB) signalling pathway is one of the key signalling pathways involved in the control and regulation of the immune system [3]. Activation of the NF-κB transcription factor is a tightly regulated event, with NF-κB normally sequestered in the cytosol of non-stimulated cells. Following activation of a cell membrane receptor and propagation of the signal via intracellular signalling to the IκB Kinase (IKK), phosphorylation-induced degradation of IκB inhibitors occurs to facilitate the release of NF-κB and its translocation to the nucleus. Dysregulation of the pathway is known to be involved in a large number of inflammatory diseases.Although considerable research has been performed since its discovery in 1986, we are still not in a position to control the signalling pathway, and thus limit the effects of NF-κB within promotion of inflammatory diseases. Through adherence to the CoSMoS framework, we are developing a computational model of the IL-1 stimulated NF-κB intracellular signalling pathway, to assist in promoting our understanding of the mechanistic behaviours within the signalling network, and therefore identify potential targets for therapeutic interventions. We have previously developed a separate domain model [4, 5] as advocated by the CoSMoS framework, which captures the essential processes and entities of the system under study using; in particular, the emergent behaviour, at an appropriate level of abstraction using a mixture of cartoon and UML diagrams, along with statistical techniques to define the temporal-spatial dynamics.

AB - The Nuclear Factor-kappa B (NF-κB) signalling pathway is one of the key signalling pathways involved in the control and regulation of the immune system [3]. Activation of the NF-κB transcription factor is a tightly regulated event, with NF-κB normally sequestered in the cytosol of non-stimulated cells. Following activation of a cell membrane receptor and propagation of the signal via intracellular signalling to the IκB Kinase (IKK), phosphorylation-induced degradation of IκB inhibitors occurs to facilitate the release of NF-κB and its translocation to the nucleus. Dysregulation of the pathway is known to be involved in a large number of inflammatory diseases.Although considerable research has been performed since its discovery in 1986, we are still not in a position to control the signalling pathway, and thus limit the effects of NF-κB within promotion of inflammatory diseases. Through adherence to the CoSMoS framework, we are developing a computational model of the IL-1 stimulated NF-κB intracellular signalling pathway, to assist in promoting our understanding of the mechanistic behaviours within the signalling network, and therefore identify potential targets for therapeutic interventions. We have previously developed a separate domain model [4, 5] as advocated by the CoSMoS framework, which captures the essential processes and entities of the system under study using; in particular, the emergent behaviour, at an appropriate level of abstraction using a mixture of cartoon and UML diagrams, along with statistical techniques to define the temporal-spatial dynamics.

M3 - Conference contribution/Paper

SN - 9781905986460

SP - 107

EP - 110

BT - CosMoS 2015

A2 - Stepney, Susan

A2 - Andrews, Paul S.

PB - Luniver Press

CY - Frome

T2 - 8th Workshop on Complex Systems Modelling and Simulation

Y2 - 20 July 2015 through 20 July 2015

ER -