Final published version
Research output: Contribution to Journal/Magazine › Review article › peer-review
Research output: Contribution to Journal/Magazine › Review article › peer-review
}
TY - JOUR
T1 - Transcription factors in neurodevelopmental and associated psychiatric disorders
T2 - A potential convergence for genetic and environmental risk factors
AU - Santos-Terra, Júlio
AU - Deckmann, Iohanna
AU - Fontes-Dutra, Mellanie
AU - Schwingel, Gustavo Brum
AU - Bambini-Junior, Victorio
AU - Gottfried, Carmem
N1 - © 2021 International Society for Developmental Neuroscience.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Neurodevelopmental disorders (NDDs) are a heterogeneous and highly prevalent group of psychiatric conditions marked by impairments in the nervous system. Their onset occurs during gestation, and the alterations are observed throughout the postnatal life. Although many genetic and environmental risk factors have been described in this context, the interactions between them challenge the understanding of the pathways associated with NDDs. Transcription factors (TFs)-a group of over 1,600 proteins that can interact with DNA, regulating gene expression through modulation of RNA synthesis-represent a point of convergence for different risk factors. In addition, TFs organize critical processes like angiogenesis, blood-brain barrier formation, myelination, neuronal migration, immune activation, and many others in a time and location-dependent way. In this review, we summarize important TF alterations in NDD and associated disorders, along with specific impairments observed in animal models, and, finally, establish hypotheses to explain how these proteins may be critical mediators in the context of genome-environment interactions.
AB - Neurodevelopmental disorders (NDDs) are a heterogeneous and highly prevalent group of psychiatric conditions marked by impairments in the nervous system. Their onset occurs during gestation, and the alterations are observed throughout the postnatal life. Although many genetic and environmental risk factors have been described in this context, the interactions between them challenge the understanding of the pathways associated with NDDs. Transcription factors (TFs)-a group of over 1,600 proteins that can interact with DNA, regulating gene expression through modulation of RNA synthesis-represent a point of convergence for different risk factors. In addition, TFs organize critical processes like angiogenesis, blood-brain barrier formation, myelination, neuronal migration, immune activation, and many others in a time and location-dependent way. In this review, we summarize important TF alterations in NDD and associated disorders, along with specific impairments observed in animal models, and, finally, establish hypotheses to explain how these proteins may be critical mediators in the context of genome-environment interactions.
KW - Animals
KW - Gene-Environment Interaction
KW - Humans
KW - Mental Disorders/etiology
KW - Neurodevelopmental Disorders/etiology
KW - Risk Factors
KW - Transcription Factors/genetics
U2 - 10.1002/jdn.10141
DO - 10.1002/jdn.10141
M3 - Review article
C2 - 34240460
VL - 81
SP - 545
EP - 578
JO - International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
JF - International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
SN - 0736-5748
IS - 7
ER -