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Transcription stress causes an inflammatory response via release of IL-1α

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Transcription stress causes an inflammatory response via release of IL-1α. / Walker, Thomas D. J.; Morris, Jessica P.; Unterholzner, Leonie.
In: Nature Structural and Molecular Biology, Vol. 32, No. 4, 14756, 30.04.2025, p. 591-594.

Research output: Contribution to Journal/Magazine › Journal article

Harvard

Walker, TDJ, Morris, JP & Unterholzner, L 2025, 'Transcription stress causes an inflammatory response via release of IL-1α', Nature Structural and Molecular Biology, vol. 32, no. 4, 14756, pp. 591-594. https://doi.org/10.1038/s41594-025-01525-5

APA

Walker, T. D. J., Morris, J. P., & Unterholzner, L. (2025). Transcription stress causes an inflammatory response via release of IL-1α. Nature Structural and Molecular Biology, 32(4), 591-594. Article 14756. https://doi.org/10.1038/s41594-025-01525-5

Vancouver

Walker TDJ, Morris JP, Unterholzner L. Transcription stress causes an inflammatory response via release of IL-1α. Nature Structural and Molecular Biology. 2025 Apr 30;32(4):591-594. 14756. Epub 2025 Apr 11. doi: 10.1038/s41594-025-01525-5

Author

Walker, Thomas D. J. ; Morris, Jessica P. ; Unterholzner, Leonie. / Transcription stress causes an inflammatory response via release of IL-1α. In: Nature Structural and Molecular Biology. 2025 ; Vol. 32, No. 4. pp. 591-594.

Bibtex

@article{0a7f6f06a3fe4a9bb49723f7a376a340,
title = "Transcription stress causes an inflammatory response via release of IL-1α",
abstract = "DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can also initiate inflammation by causing the direct release of cytokine IL-1α, which then drives NF-κB activation in neighboring cells.",
keywords = "innate immunity, transcription stress, NF-kappa B, Inflammation",
author = "Walker, {Thomas D. J.} and Morris, {Jessica P.} and Leonie Unterholzner",
year = "2025",
month = apr,
day = "30",
doi = "10.1038/s41594-025-01525-5",
language = "English",
volume = "32",
pages = "591--594",
journal = "Nature Structural and Molecular Biology",
issn = "1545-9993",
publisher = "Nature Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Transcription stress causes an inflammatory response via release of IL-1α

AU - Walker, Thomas D. J.

AU - Morris, Jessica P.

AU - Unterholzner, Leonie

PY - 2025/4/30

Y1 - 2025/4/30

N2 - DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can also initiate inflammation by causing the direct release of cytokine IL-1α, which then drives NF-κB activation in neighboring cells.

AB - DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can also initiate inflammation by causing the direct release of cytokine IL-1α, which then drives NF-κB activation in neighboring cells.

KW - innate immunity

KW - transcription stress

KW - NF-kappa B

KW - Inflammation

U2 - 10.1038/s41594-025-01525-5

DO - 10.1038/s41594-025-01525-5

M3 - Journal article

VL - 32

SP - 591

EP - 594

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

SN - 1545-9993

IS - 4

M1 - 14756

ER -