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Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG

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Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG. / Rogers, Matthew E; Ilg, Thomas; Nikolaev, Andrei V; Ferguson, Michael A J; Bates, Paul A.

In: Nature, Vol. 430, No. 6998, 22.07.2004, p. 463-467.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Rogers, ME, Ilg, T, Nikolaev, AV, Ferguson, MAJ & Bates, PA 2004, 'Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG', Nature, vol. 430, no. 6998, pp. 463-467. https://doi.org/10.1038/nature02675

APA

Rogers, M. E., Ilg, T., Nikolaev, A. V., Ferguson, M. A. J., & Bates, P. A. (2004). Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG. Nature, 430(6998), 463-467. https://doi.org/10.1038/nature02675

Vancouver

Author

Rogers, Matthew E ; Ilg, Thomas ; Nikolaev, Andrei V ; Ferguson, Michael A J ; Bates, Paul A. / Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG. In: Nature. 2004 ; Vol. 430, No. 6998. pp. 463-467.

Bibtex

@article{35cd748d7cfe448aa970cfe424658909,
title = "Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG",
abstract = "Sand flies are the exclusive vectors of the protozoan parasite Leishmania, but the mechanism of transmission by fly bite has not been determined nor incorporated into experimental models of infection. In sand flies with mature Leishmania infections the anterior midgut is blocked by a gel of parasite origin, the promastigote secretory gel. Here we analyse the inocula from Leishmania mexicana-infected Lutzomyia longipalpis sand flies. Analysis revealed the size of the infectious dose, the underlying mechanism of parasite delivery by regurgitation, and the novel contribution made to infection by filamentous proteophosphoglycan (fPPG), a component of promastigote secretory gel found to accompany the parasites during transmission. Collectively these results have important implications for understanding the relationship between the parasite and its vector, the pathology of cutaneous leishmaniasis in humans and also the development of effective vaccines and drugs. These findings emphasize that to fully understand transmission of vector-borne diseases the interaction between the parasite, its vector and the mammalian host must be considered together.",
author = "Rogers, {Matthew E} and Thomas Ilg and Nikolaev, {Andrei V} and Ferguson, {Michael A J} and Bates, {Paul A}",
year = "2004",
month = jul,
day = "22",
doi = "10.1038/nature02675",
language = "English",
volume = "430",
pages = "463--467",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6998",

}

RIS

TY - JOUR

T1 - Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG

AU - Rogers, Matthew E

AU - Ilg, Thomas

AU - Nikolaev, Andrei V

AU - Ferguson, Michael A J

AU - Bates, Paul A

PY - 2004/7/22

Y1 - 2004/7/22

N2 - Sand flies are the exclusive vectors of the protozoan parasite Leishmania, but the mechanism of transmission by fly bite has not been determined nor incorporated into experimental models of infection. In sand flies with mature Leishmania infections the anterior midgut is blocked by a gel of parasite origin, the promastigote secretory gel. Here we analyse the inocula from Leishmania mexicana-infected Lutzomyia longipalpis sand flies. Analysis revealed the size of the infectious dose, the underlying mechanism of parasite delivery by regurgitation, and the novel contribution made to infection by filamentous proteophosphoglycan (fPPG), a component of promastigote secretory gel found to accompany the parasites during transmission. Collectively these results have important implications for understanding the relationship between the parasite and its vector, the pathology of cutaneous leishmaniasis in humans and also the development of effective vaccines and drugs. These findings emphasize that to fully understand transmission of vector-borne diseases the interaction between the parasite, its vector and the mammalian host must be considered together.

AB - Sand flies are the exclusive vectors of the protozoan parasite Leishmania, but the mechanism of transmission by fly bite has not been determined nor incorporated into experimental models of infection. In sand flies with mature Leishmania infections the anterior midgut is blocked by a gel of parasite origin, the promastigote secretory gel. Here we analyse the inocula from Leishmania mexicana-infected Lutzomyia longipalpis sand flies. Analysis revealed the size of the infectious dose, the underlying mechanism of parasite delivery by regurgitation, and the novel contribution made to infection by filamentous proteophosphoglycan (fPPG), a component of promastigote secretory gel found to accompany the parasites during transmission. Collectively these results have important implications for understanding the relationship between the parasite and its vector, the pathology of cutaneous leishmaniasis in humans and also the development of effective vaccines and drugs. These findings emphasize that to fully understand transmission of vector-borne diseases the interaction between the parasite, its vector and the mammalian host must be considered together.

U2 - 10.1038/nature02675

DO - 10.1038/nature02675

M3 - Journal article

C2 - 15269771

VL - 430

SP - 463

EP - 467

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6998

ER -