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Trichinella spiralis antigens prime mixed Th1/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro

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Trichinella spiralis antigens prime mixed Th1/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro. / Ilic, N.; Worthington, John J.; Gruden-Movsesijan, A. et al.
In: Parasite Immunology, Vol. 33, No. 10, 10.2011, p. 572-582.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Ilic, N, Worthington, JJ, Gruden-Movsesijan, A, Travis, MA, Sofronic-Milosavljevic, L & Grencis, RK 2011, 'Trichinella spiralis antigens prime mixed Th1/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro', Parasite Immunology, vol. 33, no. 10, pp. 572-582. https://doi.org/10.1111/j.1365-3024.2011.01322.x

APA

Ilic, N., Worthington, J. J., Gruden-Movsesijan, A., Travis, M. A., Sofronic-Milosavljevic, L., & Grencis, R. K. (2011). Trichinella spiralis antigens prime mixed Th1/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro. Parasite Immunology, 33(10), 572-582. https://doi.org/10.1111/j.1365-3024.2011.01322.x

Vancouver

Ilic N, Worthington JJ, Gruden-Movsesijan A, Travis MA, Sofronic-Milosavljevic L, Grencis RK. Trichinella spiralis antigens prime mixed Th1/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro. Parasite Immunology. 2011 Oct;33(10):572-582. Epub 2011 Sept 13. doi: 10.1111/j.1365-3024.2011.01322.x

Author

Ilic, N. ; Worthington, John J. ; Gruden-Movsesijan, A. et al. / Trichinella spiralis antigens prime mixed Th1/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro. In: Parasite Immunology. 2011 ; Vol. 33, No. 10. pp. 572-582.

Bibtex

@article{cbdd7b42618b4701a8e9811ba354d01f,
title = "Trichinella spiralis antigens prime mixed Th1/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro",
abstract = "Many parasitic helminth infections induce Th2-type immune responses and engage the regulatory network. In this study, we specifically investigated the influence of antigens derived from different life stages of the helminth Trichinella spiralis on the polarization of naive CD4(+) T cells by dendritic cells. Results obtained from C57BL/6 mice showed that T. spiralis derived antigens have the capacity to induce bone marrow-derived dendritic cells to acquire an incompletely mature phenotype that promotes a significant proliferation of naive CD4(+) T cells and a mixed Th1/Th2 cytokine profile with the predominance of Th2 cytokines. Increased production of IL-4, IL-9, IL-10 and IL-13 accompanied increased IFN-γ. Furthermore, dendritic cells pulsed with T. spiralis antigens did not induce an increase in the population of Foxp3(+) T regulatory cells. Although other helminth antigens have demonstrated the capacity to induce de novo generation of Foxp3(+) T regulatory cells, here our in vitro studies provide no evidence that T. spiralis antigens have this capacity.",
keywords = "Animals, Antigens, Helminth, Cytokines, Dendritic Cells, Female, Forkhead Transcription Factors, Mice, Mice, Inbred C57BL, T-Lymphocyte Subsets, Trichinella spiralis",
author = "N. Ilic and Worthington, {John J.} and A. Gruden-Movsesijan and Travis, {Mark A.} and L. Sofronic-Milosavljevic and Grencis, {Richard K.}",
note = "{\textcopyright} 2011 Blackwell Publishing Ltd.",
year = "2011",
month = oct,
doi = "10.1111/j.1365-3024.2011.01322.x",
language = "English",
volume = "33",
pages = "572--582",
journal = "Parasite Immunology",
issn = "0141-9838",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - Trichinella spiralis antigens prime mixed Th1/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro

AU - Ilic, N.

AU - Worthington, John J.

AU - Gruden-Movsesijan, A.

AU - Travis, Mark A.

AU - Sofronic-Milosavljevic, L.

AU - Grencis, Richard K.

N1 - © 2011 Blackwell Publishing Ltd.

PY - 2011/10

Y1 - 2011/10

N2 - Many parasitic helminth infections induce Th2-type immune responses and engage the regulatory network. In this study, we specifically investigated the influence of antigens derived from different life stages of the helminth Trichinella spiralis on the polarization of naive CD4(+) T cells by dendritic cells. Results obtained from C57BL/6 mice showed that T. spiralis derived antigens have the capacity to induce bone marrow-derived dendritic cells to acquire an incompletely mature phenotype that promotes a significant proliferation of naive CD4(+) T cells and a mixed Th1/Th2 cytokine profile with the predominance of Th2 cytokines. Increased production of IL-4, IL-9, IL-10 and IL-13 accompanied increased IFN-γ. Furthermore, dendritic cells pulsed with T. spiralis antigens did not induce an increase in the population of Foxp3(+) T regulatory cells. Although other helminth antigens have demonstrated the capacity to induce de novo generation of Foxp3(+) T regulatory cells, here our in vitro studies provide no evidence that T. spiralis antigens have this capacity.

AB - Many parasitic helminth infections induce Th2-type immune responses and engage the regulatory network. In this study, we specifically investigated the influence of antigens derived from different life stages of the helminth Trichinella spiralis on the polarization of naive CD4(+) T cells by dendritic cells. Results obtained from C57BL/6 mice showed that T. spiralis derived antigens have the capacity to induce bone marrow-derived dendritic cells to acquire an incompletely mature phenotype that promotes a significant proliferation of naive CD4(+) T cells and a mixed Th1/Th2 cytokine profile with the predominance of Th2 cytokines. Increased production of IL-4, IL-9, IL-10 and IL-13 accompanied increased IFN-γ. Furthermore, dendritic cells pulsed with T. spiralis antigens did not induce an increase in the population of Foxp3(+) T regulatory cells. Although other helminth antigens have demonstrated the capacity to induce de novo generation of Foxp3(+) T regulatory cells, here our in vitro studies provide no evidence that T. spiralis antigens have this capacity.

KW - Animals

KW - Antigens, Helminth

KW - Cytokines

KW - Dendritic Cells

KW - Female

KW - Forkhead Transcription Factors

KW - Mice

KW - Mice, Inbred C57BL

KW - T-Lymphocyte Subsets

KW - Trichinella spiralis

U2 - 10.1111/j.1365-3024.2011.01322.x

DO - 10.1111/j.1365-3024.2011.01322.x

M3 - Journal article

C2 - 21793858

VL - 33

SP - 572

EP - 582

JO - Parasite Immunology

JF - Parasite Immunology

SN - 0141-9838

IS - 10

ER -