Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Twin peaks
T2 - The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England
AU - Elliott, Paul
AU - Eales, Oliver
AU - Steyn, Nicholas
AU - Tang, David
AU - Bodinier, Barbara
AU - Wang, Haowei
AU - Elliott, Joshua
AU - Whitaker, Matthew
AU - Atchison, Christina
AU - Diggle, Peter J.
AU - Page, Andrew J.
AU - Trotter, Alexander J.
AU - Ashby, Deborah
AU - Barclay, Wendy
AU - Taylor, Graham
AU - Ward, Helen
AU - Darzi, Ara
AU - Cooke, Graham S.
AU - Donnelly, Christl A.
AU - Chadeau-Hyam, Marc
PY - 2022/6/24
Y1 - 2022/6/24
N2 - Rapid transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has led to record-breaking incidence rates around the world. The REal-time Assessment of Community Transmission-1 (REACT-1) study has tracked SARS-CoV-2 infection in England using reverse transcription polymerase chain reaction (RT-PCR) results from self-administered throat and nose swabs from randomly selected participants aged 5+ years, approximately monthly from May 2020 to March 2022. Weighted prevalence in March 2022 was the highest recorded in REACT-1 at 6.37% (N=109,181) with Omicron BA.2 largely replacing BA.1. Prevalence was increasing overall with the greatest increase in those aged 65-74 and 75+ years. This was associated with increased hospitalizations and deaths but at much lower levels than in previous waves against a backdrop of high levels of vaccination.
AB - Rapid transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has led to record-breaking incidence rates around the world. The REal-time Assessment of Community Transmission-1 (REACT-1) study has tracked SARS-CoV-2 infection in England using reverse transcription polymerase chain reaction (RT-PCR) results from self-administered throat and nose swabs from randomly selected participants aged 5+ years, approximately monthly from May 2020 to March 2022. Weighted prevalence in March 2022 was the highest recorded in REACT-1 at 6.37% (N=109,181) with Omicron BA.2 largely replacing BA.1. Prevalence was increasing overall with the greatest increase in those aged 65-74 and 75+ years. This was associated with increased hospitalizations and deaths but at much lower levels than in previous waves against a backdrop of high levels of vaccination.
U2 - 10.1126/science.abq4411
DO - 10.1126/science.abq4411
M3 - Journal article
C2 - 35608440
VL - 376
JO - Science
JF - Science
SN - 0036-8075
IS - 6600
M1 - abq4411
ER -