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Understanding the natural progression in %FEV1 decline in patients with cystic fibrosis: a longitudinal study

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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  • David Taylor-Robinson
  • Margaret Whitehead
  • Finn Diderichsen
  • Hanne Vebert Olesen
  • Tania Pressler
  • Rosalind L Smyth
  • Peter Diggle
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<mark>Journal publication date</mark>2012
<mark>Journal</mark>Thorax
Issue number10
Volume67
Number of pages7
Pages (from-to)860-866
Publication StatusPublished
<mark>Original language</mark>English

Abstract

Forced expiratory volume in 1 s as a percentage of predicted (%FEV1) is a key outcome in cystic fibrosis (CF) and other lung diseases. As people with CF survive for longer periods, new methods are required to understand the way %FEV1 changes over time. An up to date approach for longitudinal modelling of %FEV1 is presented and applied to a unique CF dataset to demonstrate its utility at the clinical and population level.