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  • cs-2020-00471n_revised

    Rights statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright ©2020 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acscatal.0c00471

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    Available under license: CC BY-NC: Creative Commons Attribution-NonCommercial 4.0 International License

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Unraveling and manipulating of NADH oxidation by photo-generated holes

Research output: Contribution to journalLetterpeer-review

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  • Shaohua Zhang
  • Jiafu Shi
  • Yixuan Chen
  • Qian Huo
  • Weiran Li
  • Yizhou Wu
  • Yiying Sun
  • Yishan Zhang
  • Xiaodong Wang
  • Zhongyi Jiang
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<mark>Journal publication date</mark>1/05/2020
<mark>Journal</mark>ACS Catalysis
Issue number9
Volume10
Number of pages6
Pages (from-to)4967-4972
Publication StatusPublished
Early online date8/04/20
<mark>Original language</mark>English

Abstract

Photoenzymatic coupled catalysis, integrating semiconductor photocatalysis and enzymatic catalysis, exhibits great potential for light-driven synthesis. To make photocatalyst and enzyme at play concertedly, nicotinamide-based cofactors have been widely used as electron carrier. However, these cofactors are easily oxidized into enzymatically inactive form by photo-generated holes. Herein, oxidation mechanism of NADH, one typical nicotinamide-based cofactor, by photo-generated holes was reported. With CdS, g-C3N4 and BiVO4 as hole generators, NADH is oxidized into NAD+ or fragmented into ADP-ribose derivatives through multi-step electron transfer. Importantly, fragmentation reaction is inhibited with dopamine and neutral red to coordinate electron transfer between NADH and photo-generated holes.

Bibliographic note

This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright ©2020 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acscatal.0c00471