Research output: Contribution to Journal/Magazine › Comment/debate
Research output: Contribution to Journal/Magazine › Comment/debate
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TY - JOUR
T1 - Unraveling DNA sequence to identify cerebral indicators of dementia risk
AU - Masellis, Mario
AU - Knight, Jo
PY - 2018/1/16
Y1 - 2018/1/16
N2 - Dementia risk is complex: aging plus genetic, environmental, and cardiovascular factors are involved. Multiple pathologic proteins with or without cerebral small vessel disease contribute to dementia presentation. No potential disease-modifying drugs have passed the rigor of clinical trials. One likely reason for their failure is that in symptomatic dementia, the proteinopathy has taken hold, so it is too late for a drug to work. Thus, the development of novel methods to identify individuals at risk for dementia using neuroimaging biomarkers is a critical line of investigation.
AB - Dementia risk is complex: aging plus genetic, environmental, and cardiovascular factors are involved. Multiple pathologic proteins with or without cerebral small vessel disease contribute to dementia presentation. No potential disease-modifying drugs have passed the rigor of clinical trials. One likely reason for their failure is that in symptomatic dementia, the proteinopathy has taken hold, so it is too late for a drug to work. Thus, the development of novel methods to identify individuals at risk for dementia using neuroimaging biomarkers is a critical line of investigation.
U2 - 10.1212/WNL.0000000000004838
DO - 10.1212/WNL.0000000000004838
M3 - Comment/debate
C2 - 29282334
VL - 90
SP - 109
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 3
ER -