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Vibration spectroscopy of biofluids for disease screaning or diagnosis: translation from the laboratory to a clinical setting

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Vibration spectroscopy of biofluids for disease screaning or diagnosis : translation from the laboratory to a clinical setting. / Mitchell, Alana L.; Gajjar, Ketan; Theophilou, Georgios et al.

In: Journal of Biophotonics, Vol. 7, No. 3-4, 04.2014, p. 153-165.

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Mitchell AL, Gajjar K, Theophilou G, Martin FL, Martin-Hirsch PL. Vibration spectroscopy of biofluids for disease screaning or diagnosis: translation from the laboratory to a clinical setting. Journal of Biophotonics. 2014 Apr;7(3-4):153-165. Epub 2014 Mar 19. doi: 10.1002/jbio.201400018

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Mitchell, Alana L. ; Gajjar, Ketan ; Theophilou, Georgios et al. / Vibration spectroscopy of biofluids for disease screaning or diagnosis : translation from the laboratory to a clinical setting. In: Journal of Biophotonics. 2014 ; Vol. 7, No. 3-4. pp. 153-165.

Bibtex

@article{ec651774aec04df79ab8781e63c0df58,
title = "Vibration spectroscopy of biofluids for disease screaning or diagnosis: translation from the laboratory to a clinical setting",
abstract = "There remains a need for objective and cost-effective approaches capable of diagnosing early-stage disease in point-of-care clinical settings. Given an increasingly ageing population resulting in a rising prevalence of chronic diseases, the need for screening to facilitate the personalising of therapies to prevent or slow down pathology development will increase. Such a tool needs to be robust but simple enough to be implemented into clinical practice. There is interest in extracting biomarkers from biofluids (e.g., plasma or serum); techniques based on vibrational spectroscopy provide an option. Sample preparation is minimal, techniques involved are relatively low-cost, and data frameworks are available. This review explores the evidence supporting the applicability of vibrational spectroscopy to generate spectral biomarkers of disease in biofluids. We extend the inter-disciplinary nature of this approach to hypothesise a microfluidic platform that could allow such measurements. With an appropriate lightsource, such engineering could revolutionize screening in the 21st century. ",
author = "Mitchell, {Alana L.} and Ketan Gajjar and Georgios Theophilou and Martin, {Francis Luke} and Martin-Hirsch, {Pierre Leonard}",
year = "2014",
month = apr,
doi = "10.1002/jbio.201400018",
language = "English",
volume = "7",
pages = "153--165",
journal = "Journal of Biophotonics",
issn = "1864-063X",
publisher = "Wiley-VCH Verlag",
number = "3-4",

}

RIS

TY - JOUR

T1 - Vibration spectroscopy of biofluids for disease screaning or diagnosis

T2 - translation from the laboratory to a clinical setting

AU - Mitchell, Alana L.

AU - Gajjar, Ketan

AU - Theophilou, Georgios

AU - Martin, Francis Luke

AU - Martin-Hirsch, Pierre Leonard

PY - 2014/4

Y1 - 2014/4

N2 - There remains a need for objective and cost-effective approaches capable of diagnosing early-stage disease in point-of-care clinical settings. Given an increasingly ageing population resulting in a rising prevalence of chronic diseases, the need for screening to facilitate the personalising of therapies to prevent or slow down pathology development will increase. Such a tool needs to be robust but simple enough to be implemented into clinical practice. There is interest in extracting biomarkers from biofluids (e.g., plasma or serum); techniques based on vibrational spectroscopy provide an option. Sample preparation is minimal, techniques involved are relatively low-cost, and data frameworks are available. This review explores the evidence supporting the applicability of vibrational spectroscopy to generate spectral biomarkers of disease in biofluids. We extend the inter-disciplinary nature of this approach to hypothesise a microfluidic platform that could allow such measurements. With an appropriate lightsource, such engineering could revolutionize screening in the 21st century.

AB - There remains a need for objective and cost-effective approaches capable of diagnosing early-stage disease in point-of-care clinical settings. Given an increasingly ageing population resulting in a rising prevalence of chronic diseases, the need for screening to facilitate the personalising of therapies to prevent or slow down pathology development will increase. Such a tool needs to be robust but simple enough to be implemented into clinical practice. There is interest in extracting biomarkers from biofluids (e.g., plasma or serum); techniques based on vibrational spectroscopy provide an option. Sample preparation is minimal, techniques involved are relatively low-cost, and data frameworks are available. This review explores the evidence supporting the applicability of vibrational spectroscopy to generate spectral biomarkers of disease in biofluids. We extend the inter-disciplinary nature of this approach to hypothesise a microfluidic platform that could allow such measurements. With an appropriate lightsource, such engineering could revolutionize screening in the 21st century.

U2 - 10.1002/jbio.201400018

DO - 10.1002/jbio.201400018

M3 - Journal article

VL - 7

SP - 153

EP - 165

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 3-4

ER -