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Viral evasion and subversion of pattern-recognition receptor signalling

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Viral evasion and subversion of pattern-recognition receptor signalling. / Bowie, Andrew G.; Unterholzner, Leonie.

In: Nature Immunology, Vol. 8, No. 12, 12.2008, p. 911-922.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Bowie AG, Unterholzner L. Viral evasion and subversion of pattern-recognition receptor signalling. Nature Immunology. 2008 Dec;8(12):911-922. doi: 10.1038/nri2436

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Bowie, Andrew G. ; Unterholzner, Leonie. / Viral evasion and subversion of pattern-recognition receptor signalling. In: Nature Immunology. 2008 ; Vol. 8, No. 12. pp. 911-922.

Bibtex

@article{3c4d6b5a5880466ca4da62af6ce3b58e,
title = "Viral evasion and subversion of pattern-recognition receptor signalling",
abstract = "The expression of pattern-recognition receptors (PRRs) by immune and tissue cells provides the host with the ability to detect and respond to infection by viruses and other microorganisms. Significant progress has been made from studying this area, including the identification of PRRs, such as Toll-like receptors and RIG-I-like receptors, and the description of the molecular basis of their signalling pathways, which lead to the production of interferons and other cytokines. In parallel, common mechanisms used by viruses to evade PRR-mediated responses or to actively subvert these pathways for their own benefit are emerging. Accumulating evidence on how viral infection and PRR signalling pathways intersect is providing further insights into the function of the pathways involved, their constituent proteins and ways in which they could be manipulated therapeutically.",
keywords = "Animals, Host-Pathogen Interactions, Humans, Immunity, Innate, Interferons, Receptors, Pattern Recognition, Signal Transduction, Viral Proteins, Virus Diseases, Viruses",
author = "Bowie, {Andrew G.} and Leonie Unterholzner",
year = "2008",
month = dec,
doi = "10.1038/nri2436",
language = "English",
volume = "8",
pages = "911--922",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "12",

}

RIS

TY - JOUR

T1 - Viral evasion and subversion of pattern-recognition receptor signalling

AU - Bowie, Andrew G.

AU - Unterholzner, Leonie

PY - 2008/12

Y1 - 2008/12

N2 - The expression of pattern-recognition receptors (PRRs) by immune and tissue cells provides the host with the ability to detect and respond to infection by viruses and other microorganisms. Significant progress has been made from studying this area, including the identification of PRRs, such as Toll-like receptors and RIG-I-like receptors, and the description of the molecular basis of their signalling pathways, which lead to the production of interferons and other cytokines. In parallel, common mechanisms used by viruses to evade PRR-mediated responses or to actively subvert these pathways for their own benefit are emerging. Accumulating evidence on how viral infection and PRR signalling pathways intersect is providing further insights into the function of the pathways involved, their constituent proteins and ways in which they could be manipulated therapeutically.

AB - The expression of pattern-recognition receptors (PRRs) by immune and tissue cells provides the host with the ability to detect and respond to infection by viruses and other microorganisms. Significant progress has been made from studying this area, including the identification of PRRs, such as Toll-like receptors and RIG-I-like receptors, and the description of the molecular basis of their signalling pathways, which lead to the production of interferons and other cytokines. In parallel, common mechanisms used by viruses to evade PRR-mediated responses or to actively subvert these pathways for their own benefit are emerging. Accumulating evidence on how viral infection and PRR signalling pathways intersect is providing further insights into the function of the pathways involved, their constituent proteins and ways in which they could be manipulated therapeutically.

KW - Animals

KW - Host-Pathogen Interactions

KW - Humans

KW - Immunity, Innate

KW - Interferons

KW - Receptors, Pattern Recognition

KW - Signal Transduction

KW - Viral Proteins

KW - Virus Diseases

KW - Viruses

U2 - 10.1038/nri2436

DO - 10.1038/nri2436

M3 - Journal article

C2 - 18989317

VL - 8

SP - 911

EP - 922

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 12

ER -