TY - JOUR

T1 - Wirelessly triggered bioactive molecule delivery from degradable electroactive polymer films

AU - Ashton, Mark

AU - Appen, Isabel

AU - Firlak, Melike

AU - Stanhope, Naomi

AU - Schmidt, Christine E.

AU - Eisenstadt, William

AU - Hur, Byul

AU - Hardy, John

N1 - This is the peer reviewed version of the following article: Ashton, M.D., Appen, I.C., Firlak, M., Stanhope, N.E., Schmidt, C.E., Eisenstadt, W.R., Hur, B. and Hardy, J.G. (2021), Wirelessly triggered bioactive molecule delivery from degradable electroactive polymer films. Polym Int, 70: 467-474. https://doi.org/10.1002/pi.6089 Which has been published in final form at https://onlinelibrary.wiley.com/doi/10.1002/pi.6089 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

PY - 2021/4/28

Y1 - 2021/4/28

N2 - The development of stimuli‐responsive drug delivery systems offers significant opportunities for innovations in industry. It is possible to produce polymer‐based drug delivery devices enabling spatiotemporal control of the release of the drug triggered by an electrical stimulus. Here we describe the development of a wireless controller for drug delivery from conductive/electroactive polymer‐based biomaterials and demonstrate its function in vitro . The wireless polymer conduction controller device uses very low power, operating at 2.4 GHz, and has a supply voltage controller circuit which controls electrical stimulation voltage levels. The computer graphical user interface program communicates with the controller device, and it receives device information, device status and temperature data from the controller device. The prototype of the wireless controller system can trigger the delivery of a drug, dexamethasone phosphate, from a matrix of degradable electroactive polymers. Furthermore, we introduce the application of in silico toxicity screening as a potentially useful method to facilitate the design of non‐toxic degradable electroactive polymers for a multitude of biotechnological applications, addressing one of the key commercial challenges to biomaterial development, in accordance with ‘safe by design’ principles.

AB - The development of stimuli‐responsive drug delivery systems offers significant opportunities for innovations in industry. It is possible to produce polymer‐based drug delivery devices enabling spatiotemporal control of the release of the drug triggered by an electrical stimulus. Here we describe the development of a wireless controller for drug delivery from conductive/electroactive polymer‐based biomaterials and demonstrate its function in vitro . The wireless polymer conduction controller device uses very low power, operating at 2.4 GHz, and has a supply voltage controller circuit which controls electrical stimulation voltage levels. The computer graphical user interface program communicates with the controller device, and it receives device information, device status and temperature data from the controller device. The prototype of the wireless controller system can trigger the delivery of a drug, dexamethasone phosphate, from a matrix of degradable electroactive polymers. Furthermore, we introduce the application of in silico toxicity screening as a potentially useful method to facilitate the design of non‐toxic degradable electroactive polymers for a multitude of biotechnological applications, addressing one of the key commercial challenges to biomaterial development, in accordance with ‘safe by design’ principles.

KW - electroactive polymers

KW - stimuli-responsive

KW - In silico

KW - Derek nexus

KW - polymer design

KW - smart materials

KW - biomaterials

KW - drug delivery

KW - wireless control

KW - bioelectronics

U2 - 10.1002/pi.6089

DO - 10.1002/pi.6089

M3 - Journal article

VL - 70

SP - 467

EP - 474

JO - Polymer International

JF - Polymer International

SN - 0959-8103

IS - 4

ER -