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WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy. / Plastun, Valentina; Prikhozhdenko, Ekaterina; Gusliakova, Olga et al.
In: Pharmaceutics, Vol. 14, No. 6, 1199, 04.06.2022.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Plastun, V, Prikhozhdenko, E, Gusliakova, O, Raikova, S, Douglas, T, Sindeeva, O & Mayorova, O 2022, 'WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy', Pharmaceutics, vol. 14, no. 6, 1199. https://doi.org/10.3390/pharmaceutics14061199

APA

Plastun, V., Prikhozhdenko, E., Gusliakova, O., Raikova, S., Douglas, T., Sindeeva, O., & Mayorova, O. (2022). WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy. Pharmaceutics, 14(6), Article 1199. https://doi.org/10.3390/pharmaceutics14061199

Vancouver

Plastun V, Prikhozhdenko E, Gusliakova O, Raikova S, Douglas T, Sindeeva O et al. WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy. Pharmaceutics. 2022 Jun 4;14(6):1199. doi: 10.3390/pharmaceutics14061199

Author

Plastun, Valentina ; Prikhozhdenko, Ekaterina ; Gusliakova, Olga et al. / WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy. In: Pharmaceutics. 2022 ; Vol. 14, No. 6.

Bibtex

@article{e0091bec58454bc38494b8a95e817e5c,
title = "WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy",
abstract = "Infectious sequelae caused by surgery are a significant problem in modern medicine due to their reduction of therapeutic effectiveness and the patients{\textquoteright} quality of life.Recently, new methods of local antimicrobial prophylaxis of postoperative sequelae have been actively developed. They allow high local concentrations of drugs to be achieved, increasing the antibiotic therapy{\textquoteright}s effectiveness while reducing its side effects. We have developed and characterized antimicrobial hydrogels based on an inexpensive and biocompatible natural substance from the dairy industry—whey protein isolate—as matrices for drug delivery. The release of cefazolin from the pores of hydrogel structures directly depends on the amount of the loaded drug and occurs in a prolonged manner for three days. Simultaneously with the antibiotic release, hydrogel swelling and partial degradation occurs. The WPI hydrogels absorb solvent, doubling in size in three days and retaining cefazolin throughout the duration of the experiment. The antimicrobial activity of cefazolin-loaded WPI hydrogels against Staphylococcus aureus growth is prolonged in comparison to that of the free cefazolin. The overall cytotoxic effect of cefazolin-containing WPI hydrogels is lower than that of free antibiotics. Thus, our work shows that antimicrobial WPI hydrogels are suitable candidates for local antibiotic therapy of infectious surgical sequelae.",
keywords = "antimicrobial activity, hydrogel, drug release, cefazolin, whey protein isolate",
author = "Valentina Plastun and Ekaterina Prikhozhdenko and Olga Gusliakova and Svetlana Raikova and Timothy Douglas and Olga Sindeeva and Oksana Mayorova",
year = "2022",
month = jun,
day = "4",
doi = "10.3390/pharmaceutics14061199",
language = "English",
volume = "14",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",
number = "6",

}

RIS

TY - JOUR

T1 - WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy

AU - Plastun, Valentina

AU - Prikhozhdenko, Ekaterina

AU - Gusliakova, Olga

AU - Raikova, Svetlana

AU - Douglas, Timothy

AU - Sindeeva, Olga

AU - Mayorova, Oksana

PY - 2022/6/4

Y1 - 2022/6/4

N2 - Infectious sequelae caused by surgery are a significant problem in modern medicine due to their reduction of therapeutic effectiveness and the patients’ quality of life.Recently, new methods of local antimicrobial prophylaxis of postoperative sequelae have been actively developed. They allow high local concentrations of drugs to be achieved, increasing the antibiotic therapy’s effectiveness while reducing its side effects. We have developed and characterized antimicrobial hydrogels based on an inexpensive and biocompatible natural substance from the dairy industry—whey protein isolate—as matrices for drug delivery. The release of cefazolin from the pores of hydrogel structures directly depends on the amount of the loaded drug and occurs in a prolonged manner for three days. Simultaneously with the antibiotic release, hydrogel swelling and partial degradation occurs. The WPI hydrogels absorb solvent, doubling in size in three days and retaining cefazolin throughout the duration of the experiment. The antimicrobial activity of cefazolin-loaded WPI hydrogels against Staphylococcus aureus growth is prolonged in comparison to that of the free cefazolin. The overall cytotoxic effect of cefazolin-containing WPI hydrogels is lower than that of free antibiotics. Thus, our work shows that antimicrobial WPI hydrogels are suitable candidates for local antibiotic therapy of infectious surgical sequelae.

AB - Infectious sequelae caused by surgery are a significant problem in modern medicine due to their reduction of therapeutic effectiveness and the patients’ quality of life.Recently, new methods of local antimicrobial prophylaxis of postoperative sequelae have been actively developed. They allow high local concentrations of drugs to be achieved, increasing the antibiotic therapy’s effectiveness while reducing its side effects. We have developed and characterized antimicrobial hydrogels based on an inexpensive and biocompatible natural substance from the dairy industry—whey protein isolate—as matrices for drug delivery. The release of cefazolin from the pores of hydrogel structures directly depends on the amount of the loaded drug and occurs in a prolonged manner for three days. Simultaneously with the antibiotic release, hydrogel swelling and partial degradation occurs. The WPI hydrogels absorb solvent, doubling in size in three days and retaining cefazolin throughout the duration of the experiment. The antimicrobial activity of cefazolin-loaded WPI hydrogels against Staphylococcus aureus growth is prolonged in comparison to that of the free cefazolin. The overall cytotoxic effect of cefazolin-containing WPI hydrogels is lower than that of free antibiotics. Thus, our work shows that antimicrobial WPI hydrogels are suitable candidates for local antibiotic therapy of infectious surgical sequelae.

KW - antimicrobial activity

KW - hydrogel

KW - drug release

KW - cefazolin

KW - whey protein isolate

U2 - 10.3390/pharmaceutics14061199

DO - 10.3390/pharmaceutics14061199

M3 - Journal article

VL - 14

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 6

M1 - 1199

ER -