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Professor Thomas Jaki

Professor in Statistics

  1. 2020
  2. E-pub ahead of print

    A comparison of phase I dose-finding designs in clinical trials with monotonicity assumption violation

    Abbas, R., Rossoni, C., Jaki, T., Paoletti, X. & Mozgunov, P., 7/07/2020, In : Clinical Trials.

    Research output: Contribution to journalJournal article

  3. Published
  4. Published

    The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design

    Dimairo, M., Pallmann, P., Wason, J., Todd, S., Jaki, T., Julious, S. A., Mander, A. P., Weir, C. J., Koenig, F., Walton, M. K., Nicholl, J. P., Coates, E., Biggs, K., Hamasaki, T., Proschan, M. A., Scott, J. A., Ando, Y., Hind, D., Altman, D. G. & Group, ACE. C., 17/06/2020, In : Trials. 21, 1, 34 p., 528.

    Research output: Contribution to journalJournal article

  5. Published

    The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design

    Dimairo, M., Pallmann, P., Wason, J., Todd, S., Jaki, T., Julious, S. A., Mander, A. P., Weir, C. J., Koenig, F., Walton, M. K., Nicholl, J. P., Coates, E., Biggs, K., Hamasaki, T., Proschan, M. A., Scott, J. A., Ando, Y., Hind, D., Altman, D. G. & Group, ACE. C., 17/06/2020, In : BMJ. 369, 31 p., m115.

    Research output: Contribution to journalJournal article

  6. E-pub ahead of print

    Using a Dose-Finding Benchmark to Quantify the Loss Incurred by Dichotomisation in Phase II Dose-Ranging Studies

    Mozgunov, P., Jaki, T. & Paoletti, X., 11/06/2020, In : Biometrical Journal. 13 p.

    Research output: Contribution to journalJournal article

  7. E-pub ahead of print

    Using a dose-finding benchmark to quantify the loss incurred by dichotomization in Phase II dose-ranging studies

    Mozgunov, P., Jaki, T. & Paoletti, X., 11/06/2020, In : Biometrical Journal.

    Research output: Contribution to journalJournal article

  8. Published

    Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: Study protocol for a phase 3 randomized, double-blind, placebo-controlled, multicentre trial

    Wang, Y., Zhou, F., Zhang, D., Zhao, J., Du, R., Hu, Y., Cheng, Z., Gao, L., Jin, Y., Luo, G., Fu, S., Lu, Q., Du, G., Wang, K., Lu, Y., Fan, G., Zhang, Y., Liu, Y., Ruan, S., Liu, W. & 5 others, Jaki, T., Hayden, F. G., Horby, P. W., Cao, B. & Wang, C., 24/05/2020, In : Trials. 21, 1, 11 p., 422.

    Research output: Contribution to journalJournal article

  9. Published

    Estimation of treatment effects following a sequential trial of multiple treatments

    Whitehead, J., Desai, Y. & Jaki, T., 20/05/2020, In : Statistics in Medicine. 39, 11, p. 1593-1609 17 p.

    Research output: Contribution to journalJournal article

  10. Published

    Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

    Wang, Y., Zhang, D., Du, G., Du, R., Zhao, J., Jin, Y., Fu, S., Gao, L., Cheng, Z., Lu, Q., Hu, Y., Luo, G., Wang, K., Lu, Y., Li, H., Wang, S., Ruan, S., Yang, C., Mei, C., Ding, D. & 25 others, Wu, F., Tang, X., Ye, X., Ye, Y., Liu, B., Yang, J., Yin, W., Wang, A., Fan, G., Zhou, F., Liu, Z., Gu, X., Xu, J., Shang, L., Zhang, Y., Cao, L., Guo, T., Wan, Y., Qin, H., Jiang, Y., Jaki, T., Hayden, F. G., Horby, P. W., Cao, B. & Wang, C., 16/05/2020, In : The Lancet. p. 1569-1578 10 p.

    Research output: Contribution to journalJournal article

  11. Published

    TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy

    Pushpakom, S., Kolamunnage-Dona, R., Taylor, C., Foster, T., Spowart, C., García-Fiñana, M., Kemp, G. J., Jaki, T., Khoo, S., Williamson, P. & Pirmohamed, M., 15/05/2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 70, 10, p. 2062-2072 11 p.

    Research output: Contribution to journalJournal article

  12. Published

    A comparison of stochastic programming methods for portfolio level decision-making

    Graham, E., Jaki, T. & Harbron, C., 1/05/2020, In : Journal of Biopharmaceutical Statistics. 30, 3, p. 405-429 25 p.

    Research output: Contribution to journalJournal article

  13. E-pub ahead of print

    A surface-free design for phase I dual-agent combination trials

    Mozgunov, P., Gasparini, M. & Jaki, T., 27/04/2020, In : Statistical Methods in Medical Research.

    Research output: Contribution to journalJournal article

  14. Published

    Creating a framework for conducting randomized clinical trials during disease outbreaks

    Dean, N. E., Gsell, P-S., Brookmeyer, R., Crawford, F. W., Donnelly, C. A., Ellenberg, S. S., Fleming, T. R., Halloran, E. M., Horby, P., Jaki, T., Krause, P. R., Longini, I. M., Mulangu, S., Muyembe-Tamfum, J-J., Nason, M. C., Smith, P. G., Wang, R., Henao-Restrepo, A. M. & De Gruttola, V., 2/04/2020, In : New England Journal of Medicine. 382, 14, p. 1366-1369 4 p.

    Research output: Contribution to journalEditorial

  15. Published

    A benchmark for dose finding studies with continuous outcomes

    Mozgunov, P., Jaki, T. F. & Paoletti, X., 1/04/2020, In : Biostatistics. 21, 2, p. 189–201 13 p.

    Research output: Contribution to journalJournal article

  16. Published

    Repeated measures regression mixture models

    Kim, M., Van Horn, M. L., Jaki, T., Vermunt, J., Feaster, D., Lichstein, K. L., Taylor, D. J., Riedel, B. W. & Bush, A. J., 1/04/2020, In : Behavior Research Methods. 52, 2, p. 591-606 16 p.

    Research output: Contribution to journalJournal article

  17. Published

    Improving safety of the continual reassessment method via a modified allocation rule

    Mozgunov, P. & Jaki, T., 30/03/2020, In : Statistics in Medicine. 39, 7, p. 906-922 17 p.

    Research output: Contribution to journalJournal article

  18. E-pub ahead of print

    A Critical Review of Graphics for Subgroup Analyses in Clinical Trials

    Ballarini, N. M., Chiu, Y-D., Koenig, F., Posch, M. & Jaki, T., 25/03/2020, In : Pharmaceutical Statistics.

    Research output: Contribution to journalJournal article

  19. E-pub ahead of print

    Exposure–response modelling approaches for determining optimal dosing rules in children

    Wadsworth, I., Hampson, L. V., Bornkamp, B. & Jaki, T., 13/02/2020, In : Statistical Methods in Medical Research. 20 p.

    Research output: Contribution to journalJournal article

  20. Published

    A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis

    McWilliam, S. J., Rosala-Hallas, A., Jones, A. P., Shaw, V., Greenhalf, W., Jaki, T., Smyth, A. R., Smyth, R. L. & Pirmohamed, M., 4/02/2020, In : Scientific Reports. 10, 1, 9 p., 1796.

    Research output: Contribution to journalJournal article

  21. Published

    A quantitative framework to inform extrapolation decisions in children

    Wadsworth, I., Hampson, L. V., Jaki, T., Sills, G. J., Marson, A. G. & Appleton, R., 1/02/2020, In : Journal of the Royal Statistical Society: Series A Statistics in Society. 183, 2, p. 515-534 20 p.

    Research output: Contribution to journalJournal article

  22. E-pub ahead of print

    Methods for Non-Compartmental Pharmacokinetic Analysis With Observations Below the Limit of Quantification

    Barnett, H. Y., Geys, H., Jacobs, T. & Jaki, T., 21/01/2020, In : Statistics in Biopharmaceutical Research.

    Research output: Contribution to journalJournal article

  23. 2019
  24. E-pub ahead of print

    Designing and evaluating dose-escalation studies made easy: The MoDEsT web app

    Pallmann, P., Wan, F., Mander, A. P., Wheeler, G. M., Yap, C., Clive, S., Hampson, L. V. & Jaki, T., 19/12/2019, In : Clinical Trials. 10 p.

    Research output: Contribution to journalJournal article

  25. Published

    Toward Accelerated Authorization and Access to New Medicines for Juvenile Idiopathic Arthritis

    Schanberg, L. E., Ramanan, A. V., De Benedetti, F., Beukelman, T., Eakin, G. S., Del Gaizo, V., Ringold, S., Vesely, R., Schrandt, S., Jaki, T., Bili, A., Chung, J. B., De Bono, S., Douglass, W., Enejosa, J. V., Kanik, K. S., Knobe, K., Kunder, R., Leite-Schnell, J. C., Suehiro, R. M. & 6 others, Wong, R. L., Mieszkalski, K. L., Marrow, L. C., Siebenaler, K., Fraulo, E. & Kimura, Y., 1/12/2019, In : Arthritis and Rheumatology. 71, 12, p. 1976-1984 9 p.

    Research output: Contribution to journalJournal article

  26. Published

    A flexible design for advanced Phase I/II clinical trials with continuous efficacy endpoints

    Mozgunov, P. & Jaki, T., 1/11/2019, In : Biometrical Journal. 61, 6, p. 1477-1492 16 p.

    Research output: Contribution to journalJournal article

  27. Published

    Subgroup analysis of treatment effects for misclassified biomarkers with time-to-event data

    Wan, F., Titman, A. & Jaki, T., 1/11/2019, In : Journal of the Royal Statistical Society: Series C (Applied Statistics). 68, 5, p. 1447-1463 17 p.

    Research output: Contribution to journalJournal article

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