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3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide.

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3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide. / Allsop, David; Gibson, Gillian; Martin, Ian K.; Moore, Susan; Turnbull, Stuart; Twyman, Lance J.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 2, 01.2001, p. 255-257.

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Allsop, David ; Gibson, Gillian ; Martin, Ian K. ; Moore, Susan ; Turnbull, Stuart ; Twyman, Lance J. / 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide. In: Bioorganic and Medicinal Chemistry Letters. 2001 ; Vol. 11, No. 2. pp. 255-257.

Bibtex

@article{491ae54535104a41b3f691fb0232d2d9,
title = "3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide.",
abstract = "The cmc and IC50 values of the β-amyloid (Aβ) aggregation inhibitors, 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran 1, and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran 2 have been determined. After comparison of the cmc data and biological data (IC50 values), we conclude that these active benzofurans do not act as surfactants or micelles at the concentration required to inhibit β-amyloid-peptide aggregation.",
author = "David Allsop and Gillian Gibson and Martin, {Ian K.} and Susan Moore and Stuart Turnbull and Twyman, {Lance J.}",
year = "2001",
month = "1",
doi = "10.1016/S0960-894X(00)00645-4",
language = "English",
volume = "11",
pages = "255--257",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "2",

}

RIS

TY - JOUR

T1 - 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide.

AU - Allsop, David

AU - Gibson, Gillian

AU - Martin, Ian K.

AU - Moore, Susan

AU - Turnbull, Stuart

AU - Twyman, Lance J.

PY - 2001/1

Y1 - 2001/1

N2 - The cmc and IC50 values of the β-amyloid (Aβ) aggregation inhibitors, 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran 1, and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran 2 have been determined. After comparison of the cmc data and biological data (IC50 values), we conclude that these active benzofurans do not act as surfactants or micelles at the concentration required to inhibit β-amyloid-peptide aggregation.

AB - The cmc and IC50 values of the β-amyloid (Aβ) aggregation inhibitors, 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran 1, and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran 2 have been determined. After comparison of the cmc data and biological data (IC50 values), we conclude that these active benzofurans do not act as surfactants or micelles at the concentration required to inhibit β-amyloid-peptide aggregation.

U2 - 10.1016/S0960-894X(00)00645-4

DO - 10.1016/S0960-894X(00)00645-4

M3 - Journal article

VL - 11

SP - 255

EP - 257

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 2

ER -