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3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • David Allsop
  • Gillian Gibson
  • Ian K. Martin
  • Susan Moore
  • Stuart Turnbull
  • Lance J. Twyman
<mark>Journal publication date</mark>01/2001
<mark>Journal</mark>Bioorganic and Medicinal Chemistry Letters
Issue number2
Number of pages3
Pages (from-to)255-257
Publication StatusPublished
<mark>Original language</mark>English


The cmc and IC50 values of the β-amyloid (Aβ) aggregation inhibitors, 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran 1, and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran 2 have been determined. After comparison of the cmc data and biological data (IC50 values), we conclude that these active benzofurans do not act as surfactants or micelles at the concentration required to inhibit β-amyloid-peptide aggregation.