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Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to anæsthesia with propofol and sevoflurane

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Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to anæsthesia with propofol and sevoflurane. / Stankovski, Tomislav; Petkoski, Spase; Raeder, Johan; Smith, Andrew; McClintock, Peter Vaughan Elsmere; Stefanovska, Aneta.

In: Philosophical Transactions of the Royal Society of London A, Vol. 374, No. 2067, 20150186, 04.04.2016.

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Stankovski, Tomislav ; Petkoski, Spase ; Raeder, Johan ; Smith, Andrew ; McClintock, Peter Vaughan Elsmere ; Stefanovska, Aneta. / Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to anæsthesia with propofol and sevoflurane. In: Philosophical Transactions of the Royal Society of London A. 2016 ; Vol. 374, No. 2067.

Bibtex

@article{d513f647377340f99e64898f08f7c4e7,
title = "Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to an{\ae}sthesia with propofol and sevoflurane",
abstract = "The precise mechanisms underlying general an{\ae}sthesia pose important and still open questions. To address them, we have studied an{\ae}sthesia induced by the widely-used (intravenous) propofol and (inhalational) sevoflurane an{\ae}sthetics, computing cross-frequency coupling functions between neuronal, cardiac, and respiratory oscillations in order to determine their mutual interactions. The phase domain coupling function reveals the form of the function defining the mechanism of an interaction, as well as its coupling strength. Using a method based on dynamical Bayesian inference, we have thus identified and analyzed the coupling functions for six relationships. By quantitative assessment of the forms and strengths of the couplings, we have revealed how these relationships are altered by an{\ae}sthesia, also showing that some of them are differently affected by propofol and sevoflurane. These findings, together with the novel coupling function analysis, offer a new direction in the assessment of general an{\ae}sthesia and neurophysiological interactions in general.",
keywords = "Anaesthesia, Coupling function , Biological oscillations, Cortical oscillations, Cardiac oscillations, Respiratory oscillations, Propofol, Sevoflurane",
author = "Tomislav Stankovski and Spase Petkoski and Johan Raeder and Andrew Smith and McClintock, {Peter Vaughan Elsmere} and Aneta Stefanovska",
note = "c 2016 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/ by/4.0/, which permits unrestricted use, provided the original author and source are credited.",
year = "2016",
month = "4",
day = "4",
doi = "10.1098/rsta.2015.0186",
language = "English",
volume = "374",
journal = "Philosophical Transactions of the Royal Society of London A",
issn = "0264-3820",
number = "2067",

}

RIS

TY - JOUR

T1 - Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to anæsthesia with propofol and sevoflurane

AU - Stankovski, Tomislav

AU - Petkoski, Spase

AU - Raeder, Johan

AU - Smith, Andrew

AU - McClintock, Peter Vaughan Elsmere

AU - Stefanovska, Aneta

N1 - c 2016 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/ by/4.0/, which permits unrestricted use, provided the original author and source are credited.

PY - 2016/4/4

Y1 - 2016/4/4

N2 - The precise mechanisms underlying general anæsthesia pose important and still open questions. To address them, we have studied anæsthesia induced by the widely-used (intravenous) propofol and (inhalational) sevoflurane anæsthetics, computing cross-frequency coupling functions between neuronal, cardiac, and respiratory oscillations in order to determine their mutual interactions. The phase domain coupling function reveals the form of the function defining the mechanism of an interaction, as well as its coupling strength. Using a method based on dynamical Bayesian inference, we have thus identified and analyzed the coupling functions for six relationships. By quantitative assessment of the forms and strengths of the couplings, we have revealed how these relationships are altered by anæsthesia, also showing that some of them are differently affected by propofol and sevoflurane. These findings, together with the novel coupling function analysis, offer a new direction in the assessment of general anæsthesia and neurophysiological interactions in general.

AB - The precise mechanisms underlying general anæsthesia pose important and still open questions. To address them, we have studied anæsthesia induced by the widely-used (intravenous) propofol and (inhalational) sevoflurane anæsthetics, computing cross-frequency coupling functions between neuronal, cardiac, and respiratory oscillations in order to determine their mutual interactions. The phase domain coupling function reveals the form of the function defining the mechanism of an interaction, as well as its coupling strength. Using a method based on dynamical Bayesian inference, we have thus identified and analyzed the coupling functions for six relationships. By quantitative assessment of the forms and strengths of the couplings, we have revealed how these relationships are altered by anæsthesia, also showing that some of them are differently affected by propofol and sevoflurane. These findings, together with the novel coupling function analysis, offer a new direction in the assessment of general anæsthesia and neurophysiological interactions in general.

KW - Anaesthesia

KW - Coupling function

KW - Biological oscillations

KW - Cortical oscillations

KW - Cardiac oscillations

KW - Respiratory oscillations

KW - Propofol

KW - Sevoflurane

U2 - 10.1098/rsta.2015.0186

DO - 10.1098/rsta.2015.0186

M3 - Journal article

VL - 374

JO - Philosophical Transactions of the Royal Society of London A

JF - Philosophical Transactions of the Royal Society of London A

SN - 0264-3820

IS - 2067

M1 - 20150186

ER -