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Final published version, 983 KB, PDF document
Available under license: CC BY: Creative Commons Attribution 4.0 International License
Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to anæsthesia with propofol and sevoflurane
AU - Stankovski, Tomislav
AU - Petkoski, Spase
AU - Raeder, Johan
AU - Smith, Andrew
AU - McClintock, Peter Vaughan Elsmere
AU - Stefanovska, Aneta
N1 - c 2016 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/ by/4.0/, which permits unrestricted use, provided the original author and source are credited.
PY - 2016/4/4
Y1 - 2016/4/4
N2 - The precise mechanisms underlying general anæsthesia pose important and still open questions. To address them, we have studied anæsthesia induced by the widely-used (intravenous) propofol and (inhalational) sevoflurane anæsthetics, computing cross-frequency coupling functions between neuronal, cardiac, and respiratory oscillations in order to determine their mutual interactions. The phase domain coupling function reveals the form of the function defining the mechanism of an interaction, as well as its coupling strength. Using a method based on dynamical Bayesian inference, we have thus identified and analyzed the coupling functions for six relationships. By quantitative assessment of the forms and strengths of the couplings, we have revealed how these relationships are altered by anæsthesia, also showing that some of them are differently affected by propofol and sevoflurane. These findings, together with the novel coupling function analysis, offer a new direction in the assessment of general anæsthesia and neurophysiological interactions in general.
AB - The precise mechanisms underlying general anæsthesia pose important and still open questions. To address them, we have studied anæsthesia induced by the widely-used (intravenous) propofol and (inhalational) sevoflurane anæsthetics, computing cross-frequency coupling functions between neuronal, cardiac, and respiratory oscillations in order to determine their mutual interactions. The phase domain coupling function reveals the form of the function defining the mechanism of an interaction, as well as its coupling strength. Using a method based on dynamical Bayesian inference, we have thus identified and analyzed the coupling functions for six relationships. By quantitative assessment of the forms and strengths of the couplings, we have revealed how these relationships are altered by anæsthesia, also showing that some of them are differently affected by propofol and sevoflurane. These findings, together with the novel coupling function analysis, offer a new direction in the assessment of general anæsthesia and neurophysiological interactions in general.
KW - Anaesthesia
KW - Coupling function
KW - Biological oscillations
KW - Cortical oscillations
KW - Cardiac oscillations
KW - Respiratory oscillations
KW - Propofol
KW - Sevoflurane
U2 - 10.1098/rsta.2015.0186
DO - 10.1098/rsta.2015.0186
M3 - Journal article
VL - 374
JO - Philosophical Transactions of the Royal Society of London A
JF - Philosophical Transactions of the Royal Society of London A
SN - 0264-3820
IS - 2067
M1 - 20150186
ER -