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  • COOTE_Dihydropyridazines_2019_Revised

    Rights statement: This is the author’s version of a work that was accepted for publication in Tetrahedron Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron Letters, 60, 22, 2019 DOI: 10.1016/j.tetlet.2019.04.054

    Accepted author manuscript, 437 KB, PDF document

    Embargo ends: 30/04/20

    Available under license: CC BY-NC-ND

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An efficient preparation of 1,2-dihydropyridazines through a Diels-Alder/palladium-catalysed elimination sequence

Research output: Contribution to journalJournal article

Published
<mark>Journal publication date</mark>30/05/2019
<mark>Journal</mark>Tetrahedron Letters
Issue number22
Volume60
Number of pages3
Pages (from-to)1498-1500
Publication statusPublished
Early online date30/04/19
Original languageEnglish

Abstract

A convenient, scalable synthesis of 1,2-dihydropyridazines is presented, based on the Diels-Alder cycloaddition of 1-acetoxy-1,3-butadiene with a variety of azo compounds, followed by a palladium-catalysed elimination. The products are produced on multigram scale and the new method is particularly efficient and atom-economical when compared with previous preparations of 1,2-dihydropyridazines.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Tetrahedron Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron Letters, 60, 22, 2019 DOI: 10.1016/j.tetlet.2019.04.054