Environmental contours are often applied in probabilistic structural reliability analysis to identify extreme environmental conditions that may give rise to extreme loads and responses. They facilitate approximate long term analysis of critical structural responses in situations where computationally heavy and time-consuming response calculations makes full long-term analysis infeasible. The environmental contour method identifies extreme environmental conditions that are expected to give rise to extreme structural response of marine structures. The extreme responses can then be estimated by performing response calculations for environmental conditions along the contours. Response-based analysis is an alternative, where extreme value analysis is performed on the actual response rather than on the environmental conditions. For complex structures, this is often not practical due to computationally heavy response calculations. However, by establishing statistical emulators of the response, using machine learning techniques, one may obtain long time-series of the structural response and use this to estimate extreme responses. In this paper, various contour methods will be compared to response-based estimation of extreme vertical bending moment for a tanker. A response emulator based on Gaussian processes regression with adaptive sampling has been established based on response calculations from a hydrodynamic model. Long time-series of sea-state parameters such as significant wave height and wave period are used to construct N-year environmental contours and the extreme N-year response is estimated from numerical calculations for identified sea states. At the same time, the response emulator is applied on the time series to provide long time-series of structural response, in this case vertical bending moment of a tanker. Extreme value analysis is then performed directly on the responses to estimate the N-year extreme response. The results from either method will then be compared, and it is possible to evaluate the accuracy of the environmental contour method in estimating the response. Moreover, different contour methods will be compared.