Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed) › peer-review
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed) › peer-review
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TY - CHAP
T1 - Designing multi-arm multi-stage clinical studies
AU - Jaki, Thomas
PY - 2014
Y1 - 2014
N2 - In the early stages of drug development there often is uncertainty about the most promising among a set of different treatments, different doses of the same treatment or sets of combinations of treatments. An efficient solution to determine which intervention is most promising are multi-arm multi-stage clinical studies (MAMS). In this chapter we will discuss the general concept to designing MAMS studies within the group sequential framework and provide detailed solutions for multi-arm multi-stage studies with normally distributed endpoints in which all promising treatments are continued at the interim analyses. An approach to find optimal designs is discussed as well as asymptotic solutions for binary, ordinal and time-to event endpoints.
AB - In the early stages of drug development there often is uncertainty about the most promising among a set of different treatments, different doses of the same treatment or sets of combinations of treatments. An efficient solution to determine which intervention is most promising are multi-arm multi-stage clinical studies (MAMS). In this chapter we will discuss the general concept to designing MAMS studies within the group sequential framework and provide detailed solutions for multi-arm multi-stage studies with normally distributed endpoints in which all promising treatments are continued at the interim analyses. An approach to find optimal designs is discussed as well as asymptotic solutions for binary, ordinal and time-to event endpoints.
U2 - 10.1007/978-3-642-55345-5_3
DO - 10.1007/978-3-642-55345-5_3
M3 - Chapter (peer-reviewed)
SN - 9783642553448
SP - 51
EP - 69
BT - Developments in statistical evaluation of clinical trials
A2 - van Montfort, Kees
A2 - Oud, Johan
A2 - Ghidey, Wendimagegn
PB - Springer
CY - Berlin
ER -