Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Estimation of pharmacokinetic parameters with the R package PK.
AU - Jaki, Thomas
AU - Wolfsegger, Martin J.
PY - 2011/5
Y1 - 2011/5
N2 - The study of the pharmacokinetic (PK) behavior of a compound is crucial to understand the absorbtion, distribution, metabolism and elimination of a drug by the body. PK studies involve measuring the concentration of the drug in the plasma or blood at several time points post drug administration. The classic complete data design samples each subject at all predefined time points. Ethical considerations and restrictions in blood volume, however, lead to incomplete data designs being frequently used instead. In serial sampling designs only one sample is taken from each subject, whereas batch designs take samples more than once from each subject, but not at all time points. In this manuscript the R package PK, which enables the computation of various PK parameters in complete and incomplete data designs, is introduced and some examples are given.
AB - The study of the pharmacokinetic (PK) behavior of a compound is crucial to understand the absorbtion, distribution, metabolism and elimination of a drug by the body. PK studies involve measuring the concentration of the drug in the plasma or blood at several time points post drug administration. The classic complete data design samples each subject at all predefined time points. Ethical considerations and restrictions in blood volume, however, lead to incomplete data designs being frequently used instead. In serial sampling designs only one sample is taken from each subject, whereas batch designs take samples more than once from each subject, but not at all time points. In this manuscript the R package PK, which enables the computation of various PK parameters in complete and incomplete data designs, is introduced and some examples are given.
KW - AUC
KW - bioequivalence
KW - pharmacokinetics
KW - PK
KW - R
KW - toxicology
U2 - 10.1002/pst.449
DO - 10.1002/pst.449
M3 - Journal article
VL - 10
SP - 284
EP - 288
JO - Pharmaceutical Statistics
JF - Pharmaceutical Statistics
SN - 1539-1604
IS - 2
ER -