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From the potential of the mean force to a quasiparticle’s effective potential in narrow ion channels

Research output: Contribution to journalJournal article

Published
Article number1940006
<mark>Journal publication date</mark>1/06/2019
<mark>Journal</mark>Fluctuation and Noise Letters
Issue number2
Volume18
Number of pages13
Publication statusPublished
Early online date14/03/19
Original languageEnglish

Abstract

We consider the selective permeation of ions through narrow water-filled channels in the presence of strong interaction between the ions. These interactions lead to highly correlated ionic motion, which can conveniently be described via the concept of a quasiparticle. Here, we connect the quasiparticle’s effective potential and the multi-ion potential of the mean force, found through molecular dynamics simulations, and we validate the method on an analytical toy model of the KcsA channel. Possible future applications of the method to the connection between molecular dynamical calculations and the experimentally measured current-voltage and current-concentration characteristics of the channel are discussed.