This paper presents a curriculum intervention intentionally designed to align with
Next Generation Science Standards in the high-school biology classroom. The project emphasizes learning about complex systems through an agent-based modeling tool called StarLogo Nova. Five curricular units have been developed on the topics of enzymes, ecology, protein synthesis, gene regulation, and sugar transport. In this exploratory study we were interested in understanding the extent to which students demonstrated understanding and skills in NGSS areas as they were designed. Evidence is gleaned from classroom observations and
interviews with 50 students selected from the larger population of 352 students who worked with project resources during the 2013-2014 school year. Findings revealed that students demonstrated understanding and skills in all NGSS scientific practices and crosscutting themes particularly in the areas of developing and using models, analyzing and interpreting data, cause and effect, and systems and system models.