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Investigating the assumption of homogeneity of treatment effects in clincal studies with application to meta-analysis
Research output: Contribution to journal › Journal article
Published
Associated organisational units
| Journal publication date | 01/2012 |
|---|---|
| Journal | Pharmaceutical Statistics |
| Issue | 1 |
| Volume | 11 |
| Number of pages | 8 |
| Pages | 49-56 |
| Early online date | 2/12/11 |
| Original language | English |
Abstract
An important part of the evaluation of a therapy is an investigation of the assumption of homogeneity of its effect across pre-defined subpopulations. In this paper we describe simple graphical presentations that could be used to assess the homogeneity of treatment effect and identify outliers. The emphasis in the paper is on meta-analysis but the methods described can be generalized to other investigations.