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Investigating the assumption of homogeneity of treatment effects in clincal studies with application to meta-analysis

Research output: Contribution to journalJournal article

Published

Journal publication date01/2012
JournalPharmaceutical Statistics
Journal number1
Volume11
Number of pages8
Pages49-56
Early online date2/12/11
Original languageEnglish

Abstract

An important part of the evaluation of a therapy is an investigation of the assumption of homogeneity of its effect across pre-defined subpopulations. In this paper we describe simple graphical presentations that could be used to assess the homogeneity of treatment effect and identify outliers. The emphasis in the paper is on meta-analysis but the methods described can be generalized to other investigations.