Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Investigating the assumption of homogeneity of treatment effects in clincal studies with application to meta-analysis
AU - Julious, Steven
AU - Whitehead, Anne
PY - 2012/1
Y1 - 2012/1
N2 - An important part of the evaluation of a therapy is an investigation of the assumption of homogeneity of its effect across pre-defined subpopulations. In this paper we describe simple graphical presentations that could be used to assess the homogeneity of treatment effect and identify outliers. The emphasis in the paper is on meta-analysis but the methods described can be generalized to other investigations.
AB - An important part of the evaluation of a therapy is an investigation of the assumption of homogeneity of its effect across pre-defined subpopulations. In this paper we describe simple graphical presentations that could be used to assess the homogeneity of treatment effect and identify outliers. The emphasis in the paper is on meta-analysis but the methods described can be generalized to other investigations.
KW - meta-analysis
KW - clinical trials
KW - normal probability plots
KW - simulated envelopes
KW - bootstrapping
U2 - 10.1002/pst.494
DO - 10.1002/pst.494
M3 - Journal article
VL - 11
SP - 49
EP - 56
JO - Pharmaceutical Statistics
JF - Pharmaceutical Statistics
SN - 1539-1604
IS - 1
ER -