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    Rights statement: © Knight et al; licensee BioMed Central Ltd 2003 This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait

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Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait. / Knight, Jo; North, Bernard V.; Sham, Pak C.; Curtis, David.

In: Genetics, Vol. 4 , No. Suppl. 1, S74, 31.12.2003.

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Knight, Jo ; North, Bernard V. ; Sham, Pak C. ; Curtis, David. / Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait. In: Genetics. 2003 ; Vol. 4 , No. Suppl. 1.

Bibtex

@article{f5d4517c8a5f4c648030f762b3a42919,
title = "Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait",
abstract = "This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits.",
keywords = "Adult Children, Age Factors, Blood Pressure, Chromosome Mapping, Chromosomes, Human, Pair 4, Chromosomes, Human, Pair 5, Chromosomes, Human, Pair 8, Cohort Studies, Epidemiologic Studies, Family, Female, Genetic Testing, Genome, Human, Humans, Hypertension, Lod Score, Male, Models, Genetic, Pedigree, Quantitative Trait Loci",
author = "Jo Knight and North, {Bernard V.} and Sham, {Pak C.} and David Curtis",
note = "{\textcopyright} Knight et al; licensee BioMed Central Ltd 2003 This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",
year = "2003",
month = dec
day = "31",
doi = "10.1186/1471-2156-4-S1-S74",
language = "English",
volume = "4 ",
journal = "Genetics",
issn = "0016-6731",
publisher = "Genetics Society of America",
number = "Suppl. 1",

}

RIS

TY - JOUR

T1 - Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait

AU - Knight, Jo

AU - North, Bernard V.

AU - Sham, Pak C.

AU - Curtis, David

N1 - © Knight et al; licensee BioMed Central Ltd 2003 This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2003/12/31

Y1 - 2003/12/31

N2 - This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits.

AB - This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits.

KW - Adult Children

KW - Age Factors

KW - Blood Pressure

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 4

KW - Chromosomes, Human, Pair 5

KW - Chromosomes, Human, Pair 8

KW - Cohort Studies

KW - Epidemiologic Studies

KW - Family

KW - Female

KW - Genetic Testing

KW - Genome, Human

KW - Humans

KW - Hypertension

KW - Lod Score

KW - Male

KW - Models, Genetic

KW - Pedigree

KW - Quantitative Trait Loci

U2 - 10.1186/1471-2156-4-S1-S74

DO - 10.1186/1471-2156-4-S1-S74

M3 - Journal article

C2 - 14975142

VL - 4

JO - Genetics

JF - Genetics

SN - 0016-6731

IS - Suppl. 1

M1 - S74

ER -