Rights statement: © Knight et al; licensee BioMed Central Ltd 2003 This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait
AU - Knight, Jo
AU - North, Bernard V.
AU - Sham, Pak C.
AU - Curtis, David
N1 - © Knight et al; licensee BioMed Central Ltd 2003 This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
PY - 2003/12/31
Y1 - 2003/12/31
N2 - This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits.
AB - This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits.
KW - Adult Children
KW - Age Factors
KW - Blood Pressure
KW - Chromosome Mapping
KW - Chromosomes, Human, Pair 4
KW - Chromosomes, Human, Pair 5
KW - Chromosomes, Human, Pair 8
KW - Cohort Studies
KW - Epidemiologic Studies
KW - Family
KW - Female
KW - Genetic Testing
KW - Genome, Human
KW - Humans
KW - Hypertension
KW - Lod Score
KW - Male
KW - Models, Genetic
KW - Pedigree
KW - Quantitative Trait Loci
U2 - 10.1186/1471-2156-4-S1-S74
DO - 10.1186/1471-2156-4-S1-S74
M3 - Journal article
C2 - 14975142
VL - 4
JO - Genetics
JF - Genetics
SN - 0016-6731
IS - Suppl. 1
M1 - S74
ER -