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  • SPIE2007SelectivityAndGating

    Rights statement: D. G. Luchinsky; R. Tindjong; P. V. E. McClintock; I. Kaufman; R. S. Eisenberg, "On selectivity and gating of ionic channels" Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, Proceedings of the Society of Photo-Optical Instruentation Engineers (SPIE), Vol. 6602, 66020D, 2007. Copyright 2007 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.724703

    Final published version, 562 KB, PDF document

  • FN07-FN103-25PostPrint

    Rights statement: D. G. Luchinsky; R. Tindjong; P. V. E. McClintock; I. Kaufman; R. S. Eisenberg, "On selectivity and gating of ionic channels" Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, Proceedings of the Society of Photo-Optical Instruentation Engineers (SPIE), Vol. 6602, 66020D, 2007. Copyright 2007 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.724703

    Accepted author manuscript, 258 KB, PDF document

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On selectivity and gating of ionic channels

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Abstract

A novel conceptual model is introduced in which ion permeation is coupled to the protein wall vibration and the later in turn modulates exponentially strongly the permeation via radial oscillations of the potential of mean force. In the framework of this model of ion-wall-water interaction we discuss problems of selectivity between alike ions and coupling of ion permeation to gating.

Bibliographic note

D. G. Luchinsky; R. Tindjong; P. V. E. McClintock; I. Kaufman; R. S. Eisenberg, "On selectivity and gating of ionic channels" Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, Proceedings of the Society of Photo-Optical Instruentation Engineers (SPIE), Vol. 6602, 66020D, 2007. Copyright 2007 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.724703