Rights statement: D. G. Luchinsky; R. Tindjong; P. V. E. McClintock; I. Kaufman; R. S. Eisenberg, "On selectivity and gating of ionic channels" Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, Proceedings of the Society of Photo-Optical Instruentation Engineers (SPIE), Vol. 6602, 66020D, 2007. Copyright 2007 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.724703
Final published version, 562 KB, PDF document
Rights statement: D. G. Luchinsky; R. Tindjong; P. V. E. McClintock; I. Kaufman; R. S. Eisenberg, "On selectivity and gating of ionic channels" Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, Proceedings of the Society of Photo-Optical Instruentation Engineers (SPIE), Vol. 6602, 66020D, 2007. Copyright 2007 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.724703
Accepted author manuscript, 258 KB, PDF document
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
}
TY - GEN
T1 - On selectivity and gating of ionic channels
AU - Luchinsky, D. G.
AU - Tindjong, R.
AU - McClintock, P. V. E.
AU - Kaufman, I.
AU - Eisenberg, R. S.
N1 - D. G. Luchinsky; R. Tindjong; P. V. E. McClintock; I. Kaufman; R. S. Eisenberg, "On selectivity and gating of ionic channels" Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, Proceedings of the Society of Photo-Optical Instruentation Engineers (SPIE), Vol. 6602, 66020D, 2007. Copyright 2007 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.724703
PY - 2007
Y1 - 2007
N2 - A novel conceptual model is introduced in which ion permeation is coupled to the protein wall vibration and the later in turn modulates exponentially strongly the permeation via radial oscillations of the potential of mean force. In the framework of this model of ion-wall-water interaction we discuss problems of selectivity between alike ions and coupling of ion permeation to gating.
AB - A novel conceptual model is introduced in which ion permeation is coupled to the protein wall vibration and the later in turn modulates exponentially strongly the permeation via radial oscillations of the potential of mean force. In the framework of this model of ion-wall-water interaction we discuss problems of selectivity between alike ions and coupling of ion permeation to gating.
KW - ion channels
KW - selectivity
KW - gating
KW - protein vibration
KW - BROWNIAN DYNAMICS SIMULATIONS
KW - MONTE-CARLO SIMULATIONS
KW - POTASSIUM CHANNELS
KW - MOLECULAR-BASIS
KW - PERMEATION
KW - GRAMICIDIN
KW - CHARGE
KW - TRANSITION
KW - CONTINUUM
KW - MODEL
U2 - 10.1117/12.724703
DO - 10.1117/12.724703
M3 - Conference contribution/Paper
SN - 9780819467393
T3 - PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE)
BT - Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems
A2 - Bezrukov, S. M.
PB - SPIE
CY - Bellingham, Wash.
T2 - Conference on Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems
Y2 - 21 May 2007 through 23 May 2007
ER -