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  • ARC2_BJP_JPC_Adverstiy_MA_March_2016

    Rights statement: https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/relationship-between-childhood-adversity-and-bipolar-affective-disorder-systematic-review-and-metaanalysis/874AA2A1899F751049235F7953299350 The final, definitive version of this article has been published in the British Journal of Psychiatry, 209 (6), pp 454-459 2016, © 2016 Cambridge University Press.

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Relationship between childhood adversity and bipolar affective disorder: A systematic review and meta-analysis

Research output: Contribution to journalJournal article

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<mark>Journal publication date</mark>1/12/2016
<mark>Journal</mark>British Journal of Psychiatry
Issue number6
Volume209
Number of pages6
Pages (from-to)454-459
Publication statusPublished
Early online date6/10/16
Original languageEnglish

Abstract

Background
The relationship between childhood adversity and bipolar affective disorder remains unclear.

Aims
To understand the size and significance of this effect through a statistical synthesis of reported research.

Method
Search terms relating to childhood adversity and bipolar disorder were entered into Medline, EMBASE, PsycINFO and Web of Science. Eligible studies included a sample diagnosed with bipolar disorder, a comparison sample and a quantitative measure of childhood adversity.

Results
In 19 eligible studies childhood adversity was 2.63 times (95% CI 2.00–3.47) more likely to have occurred in bipolar disorder compared with non-clinical controls. The effect of emotional abuse was particularly robust (OR = 4.04, 95% CI 3.12–5.22), but rates of adversity were similar to those in psychiatric controls.

Conclusions
Childhood adversity is associated with bipolar disorder, which has implications for the treatment of this clinical group. Further prospective research could clarify temporal causality and explanatory mechanisms.

Bibliographic note

https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/relationship-between-childhood-adversity-and-bipolar-affective-disorder-systematic-review-and-metaanalysis/874AA2A1899F751049235F7953299350 The final, definitive version of this article has been published in the British Journal of Psychiatry, 209 (6), pp 454-459 2016, © 2016 Cambridge University Press.