Rights statement: https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/relationship-between-childhood-adversity-and-bipolar-affective-disorder-systematic-review-and-metaanalysis/874AA2A1899F751049235F7953299350 The final, definitive version of this article has been published in the British Journal of Psychiatry, 209 (6), pp 454-459 2016, © 2016 Cambridge University Press.
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Relationship between childhood adversity and bipolar affective disorder
T2 - A systematic review and meta-analysis
AU - Palmier-Claus, J.E.
AU - Berry, K.
AU - Bucci, S.
AU - Mansell, W.
AU - Varese, F.
N1 - https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/relationship-between-childhood-adversity-and-bipolar-affective-disorder-systematic-review-and-metaanalysis/874AA2A1899F751049235F7953299350 The final, definitive version of this article has been published in the British Journal of Psychiatry, 209 (6), pp 454-459 2016, © 2016 Cambridge University Press.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - BackgroundThe relationship between childhood adversity and bipolar affective disorder remains unclear.AimsTo understand the size and significance of this effect through a statistical synthesis of reported research.MethodSearch terms relating to childhood adversity and bipolar disorder were entered into Medline, EMBASE, PsycINFO and Web of Science. Eligible studies included a sample diagnosed with bipolar disorder, a comparison sample and a quantitative measure of childhood adversity.ResultsIn 19 eligible studies childhood adversity was 2.63 times (95% CI 2.00–3.47) more likely to have occurred in bipolar disorder compared with non-clinical controls. The effect of emotional abuse was particularly robust (OR = 4.04, 95% CI 3.12–5.22), but rates of adversity were similar to those in psychiatric controls.ConclusionsChildhood adversity is associated with bipolar disorder, which has implications for the treatment of this clinical group. Further prospective research could clarify temporal causality and explanatory mechanisms.
AB - BackgroundThe relationship between childhood adversity and bipolar affective disorder remains unclear.AimsTo understand the size and significance of this effect through a statistical synthesis of reported research.MethodSearch terms relating to childhood adversity and bipolar disorder were entered into Medline, EMBASE, PsycINFO and Web of Science. Eligible studies included a sample diagnosed with bipolar disorder, a comparison sample and a quantitative measure of childhood adversity.ResultsIn 19 eligible studies childhood adversity was 2.63 times (95% CI 2.00–3.47) more likely to have occurred in bipolar disorder compared with non-clinical controls. The effect of emotional abuse was particularly robust (OR = 4.04, 95% CI 3.12–5.22), but rates of adversity were similar to those in psychiatric controls.ConclusionsChildhood adversity is associated with bipolar disorder, which has implications for the treatment of this clinical group. Further prospective research could clarify temporal causality and explanatory mechanisms.
U2 - 10.1192/bjp.bp.115.179655
DO - 10.1192/bjp.bp.115.179655
M3 - Journal article
VL - 209
SP - 454
EP - 459
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
SN - 0007-1250
IS - 6
ER -