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    Rights statement: https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/relationship-between-childhood-adversity-and-bipolar-affective-disorder-systematic-review-and-metaanalysis/874AA2A1899F751049235F7953299350 The final, definitive version of this article has been published in the British Journal of Psychiatry, 209 (6), pp 454-459 2016, © 2016 Cambridge University Press.

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Relationship between childhood adversity and bipolar affective disorder: A systematic review and meta-analysis

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Relationship between childhood adversity and bipolar affective disorder : A systematic review and meta-analysis. / Palmier-Claus, J.E.; Berry, K.; Bucci, S.; Mansell, W.; Varese, F.

In: British Journal of Psychiatry, Vol. 209, No. 6, 01.12.2016, p. 454-459.

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Palmier-Claus, J.E. ; Berry, K. ; Bucci, S. ; Mansell, W. ; Varese, F. / Relationship between childhood adversity and bipolar affective disorder : A systematic review and meta-analysis. In: British Journal of Psychiatry. 2016 ; Vol. 209, No. 6. pp. 454-459.

Bibtex

@article{36c683984d30470aa2cf87d356b4e2f6,
title = "Relationship between childhood adversity and bipolar affective disorder: A systematic review and meta-analysis",
abstract = "BackgroundThe relationship between childhood adversity and bipolar affective disorder remains unclear.AimsTo understand the size and significance of this effect through a statistical synthesis of reported research.MethodSearch terms relating to childhood adversity and bipolar disorder were entered into Medline, EMBASE, PsycINFO and Web of Science. Eligible studies included a sample diagnosed with bipolar disorder, a comparison sample and a quantitative measure of childhood adversity.ResultsIn 19 eligible studies childhood adversity was 2.63 times (95% CI 2.00–3.47) more likely to have occurred in bipolar disorder compared with non-clinical controls. The effect of emotional abuse was particularly robust (OR = 4.04, 95% CI 3.12–5.22), but rates of adversity were similar to those in psychiatric controls.ConclusionsChildhood adversity is associated with bipolar disorder, which has implications for the treatment of this clinical group. Further prospective research could clarify temporal causality and explanatory mechanisms.",
author = "J.E. Palmier-Claus and K. Berry and S. Bucci and W. Mansell and F. Varese",
note = "https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/relationship-between-childhood-adversity-and-bipolar-affective-disorder-systematic-review-and-metaanalysis/874AA2A1899F751049235F7953299350 The final, definitive version of this article has been published in the British Journal of Psychiatry, 209 (6), pp 454-459 2016, {\textcopyright} 2016 Cambridge University Press.",
year = "2016",
month = dec,
day = "1",
doi = "10.1192/bjp.bp.115.179655",
language = "English",
volume = "209",
pages = "454--459",
journal = "British Journal of Psychiatry",
issn = "0007-1250",
publisher = "Royal College of Psychiatrists",
number = "6",

}

RIS

TY - JOUR

T1 - Relationship between childhood adversity and bipolar affective disorder

T2 - A systematic review and meta-analysis

AU - Palmier-Claus, J.E.

AU - Berry, K.

AU - Bucci, S.

AU - Mansell, W.

AU - Varese, F.

N1 - https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/relationship-between-childhood-adversity-and-bipolar-affective-disorder-systematic-review-and-metaanalysis/874AA2A1899F751049235F7953299350 The final, definitive version of this article has been published in the British Journal of Psychiatry, 209 (6), pp 454-459 2016, © 2016 Cambridge University Press.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - BackgroundThe relationship between childhood adversity and bipolar affective disorder remains unclear.AimsTo understand the size and significance of this effect through a statistical synthesis of reported research.MethodSearch terms relating to childhood adversity and bipolar disorder were entered into Medline, EMBASE, PsycINFO and Web of Science. Eligible studies included a sample diagnosed with bipolar disorder, a comparison sample and a quantitative measure of childhood adversity.ResultsIn 19 eligible studies childhood adversity was 2.63 times (95% CI 2.00–3.47) more likely to have occurred in bipolar disorder compared with non-clinical controls. The effect of emotional abuse was particularly robust (OR = 4.04, 95% CI 3.12–5.22), but rates of adversity were similar to those in psychiatric controls.ConclusionsChildhood adversity is associated with bipolar disorder, which has implications for the treatment of this clinical group. Further prospective research could clarify temporal causality and explanatory mechanisms.

AB - BackgroundThe relationship between childhood adversity and bipolar affective disorder remains unclear.AimsTo understand the size and significance of this effect through a statistical synthesis of reported research.MethodSearch terms relating to childhood adversity and bipolar disorder were entered into Medline, EMBASE, PsycINFO and Web of Science. Eligible studies included a sample diagnosed with bipolar disorder, a comparison sample and a quantitative measure of childhood adversity.ResultsIn 19 eligible studies childhood adversity was 2.63 times (95% CI 2.00–3.47) more likely to have occurred in bipolar disorder compared with non-clinical controls. The effect of emotional abuse was particularly robust (OR = 4.04, 95% CI 3.12–5.22), but rates of adversity were similar to those in psychiatric controls.ConclusionsChildhood adversity is associated with bipolar disorder, which has implications for the treatment of this clinical group. Further prospective research could clarify temporal causality and explanatory mechanisms.

U2 - 10.1192/bjp.bp.115.179655

DO - 10.1192/bjp.bp.115.179655

M3 - Journal article

VL - 209

SP - 454

EP - 459

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

IS - 6

ER -