Home > Research > Publications & Outputs > Self-consistent analytic solution for the curre...

Associated organisational unit

Electronic data

Links

Text available via DOI:

View graph of relations

Self-consistent analytic solution for the current and the access resistance in open ion channels.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published
<mark>Journal publication date</mark>2009
<mark>Journal</mark>Physical Review E
Issue number2
Volume80, 02
Publication StatusPublished
<mark>Original language</mark>English

Abstract

A self-consistent analytic approach is introduced for the estimation of the access resistance and the current through an open ion channel for an arbitrary number of species. For an ion current flowing radially inward from infinity to the channel mouth, the Poisson-Boltzmann-Nernst-Planck equations are solved analytically in the bulk with spherical symmetry in three dimensions, by linearization. Within the channel, the Poisson-Nernst-Planck equation is solved analytically in a one-dimensional approximation. An iterative procedure is used to match the two solutions together at the channel mouth in a self-consistent way. It is shown that the currentvoltage characteristics obtained are in good quantitative agreement with experimental measurements.