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The X proteins of bornaviruses interfere with type I interferon signalling

Research output: Contribution to journalJournal article

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  • Jonas Johansson Wensman
  • Muhammad Munir
  • Srinivas Thaduri
  • Katarina Hörnaeus
  • Muhammad Rizwan
  • Anne-Lie Blomström
  • Thomas Briese
  • W Ian Lipkin
  • Mikael Berg
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<mark>Journal publication date</mark>02/2013
<mark>Journal</mark>Journal of General Virology
Issue number2
Volume94
Number of pages7
Pages (from-to)263-269
Publication statusPublished
Original languageEnglish

Abstract

Borna disease virus (BDV) is a neurotropic, negative-stranded RNA virus causing persistent infection and progressive neurological disorders in a wide range of warm-blooded animals. The role of the small non-structural X protein in viral pathogenesis is not completely understood. Here we investigated whether the X protein of BDV and avian bornavirus (ABV) interferes with the type I interferon (IFN) system, similar to other non-structural proteins of negative-stranded RNA viruses. In luciferase reporter assays, we found that the X protein of various bornaviruses interfered with the type I IFN system at all checkpoints investigated, in contrast to previously reported findings, resulting in reduced type I IFN secretion.