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The X proteins of bornaviruses interfere with type I interferon signalling

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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The X proteins of bornaviruses interfere with type I interferon signalling. / Wensman, Jonas Johansson; Munir, Muhammad; Thaduri, Srinivas et al.
In: Journal of General Virology, Vol. 94, No. 2, 02.2013, p. 263-269.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Wensman, JJ, Munir, M, Thaduri, S, Hörnaeus, K, Rizwan, M, Blomström, A-L, Briese, T, Lipkin, WI & Berg, M 2013, 'The X proteins of bornaviruses interfere with type I interferon signalling', Journal of General Virology, vol. 94, no. 2, pp. 263-269. https://doi.org/10.1099/vir.0.047175-0

APA

Wensman, J. J., Munir, M., Thaduri, S., Hörnaeus, K., Rizwan, M., Blomström, A-L., Briese, T., Lipkin, W. I., & Berg, M. (2013). The X proteins of bornaviruses interfere with type I interferon signalling. Journal of General Virology, 94(2), 263-269. https://doi.org/10.1099/vir.0.047175-0

Vancouver

Wensman JJ, Munir M, Thaduri S, Hörnaeus K, Rizwan M, Blomström A-L et al. The X proteins of bornaviruses interfere with type I interferon signalling. Journal of General Virology. 2013 Feb;94(2):263-269. doi: 10.1099/vir.0.047175-0

Author

Wensman, Jonas Johansson ; Munir, Muhammad ; Thaduri, Srinivas et al. / The X proteins of bornaviruses interfere with type I interferon signalling. In: Journal of General Virology. 2013 ; Vol. 94, No. 2. pp. 263-269.

Bibtex

@article{5b10347859cf4961b066dcf0776f23c0,
title = "The X proteins of bornaviruses interfere with type I interferon signalling",
abstract = "Borna disease virus (BDV) is a neurotropic, negative-stranded RNA virus causing persistent infection and progressive neurological disorders in a wide range of warm-blooded animals. The role of the small non-structural X protein in viral pathogenesis is not completely understood. Here we investigated whether the X protein of BDV and avian bornavirus (ABV) interferes with the type I interferon (IFN) system, similar to other non-structural proteins of negative-stranded RNA viruses. In luciferase reporter assays, we found that the X protein of various bornaviruses interfered with the type I IFN system at all checkpoints investigated, in contrast to previously reported findings, resulting in reduced type I IFN secretion.",
keywords = "Animals, Bornaviridae, Cell Line, Epithelial Cells, Genes, Reporter, Humans, Immune Evasion, Interferon Type I, Luciferases, Molecular Sequence Data, RNA, Viral, Sequence Analysis, DNA, Viral Nonstructural Proteins, Virulence Factors, Journal Article, Research Support, Non-U.S. Gov't",
author = "Wensman, {Jonas Johansson} and Muhammad Munir and Srinivas Thaduri and Katarina H{\"o}rnaeus and Muhammad Rizwan and Anne-Lie Blomstr{\"o}m and Thomas Briese and Lipkin, {W Ian} and Mikael Berg",
year = "2013",
month = feb,
doi = "10.1099/vir.0.047175-0",
language = "English",
volume = "94",
pages = "263--269",
journal = "Journal of General Virology",
issn = "0022-1317",
publisher = "Society for General Microbiology",
number = "2",

}

RIS

TY - JOUR

T1 - The X proteins of bornaviruses interfere with type I interferon signalling

AU - Wensman, Jonas Johansson

AU - Munir, Muhammad

AU - Thaduri, Srinivas

AU - Hörnaeus, Katarina

AU - Rizwan, Muhammad

AU - Blomström, Anne-Lie

AU - Briese, Thomas

AU - Lipkin, W Ian

AU - Berg, Mikael

PY - 2013/2

Y1 - 2013/2

N2 - Borna disease virus (BDV) is a neurotropic, negative-stranded RNA virus causing persistent infection and progressive neurological disorders in a wide range of warm-blooded animals. The role of the small non-structural X protein in viral pathogenesis is not completely understood. Here we investigated whether the X protein of BDV and avian bornavirus (ABV) interferes with the type I interferon (IFN) system, similar to other non-structural proteins of negative-stranded RNA viruses. In luciferase reporter assays, we found that the X protein of various bornaviruses interfered with the type I IFN system at all checkpoints investigated, in contrast to previously reported findings, resulting in reduced type I IFN secretion.

AB - Borna disease virus (BDV) is a neurotropic, negative-stranded RNA virus causing persistent infection and progressive neurological disorders in a wide range of warm-blooded animals. The role of the small non-structural X protein in viral pathogenesis is not completely understood. Here we investigated whether the X protein of BDV and avian bornavirus (ABV) interferes with the type I interferon (IFN) system, similar to other non-structural proteins of negative-stranded RNA viruses. In luciferase reporter assays, we found that the X protein of various bornaviruses interfered with the type I IFN system at all checkpoints investigated, in contrast to previously reported findings, resulting in reduced type I IFN secretion.

KW - Animals

KW - Bornaviridae

KW - Cell Line

KW - Epithelial Cells

KW - Genes, Reporter

KW - Humans

KW - Immune Evasion

KW - Interferon Type I

KW - Luciferases

KW - Molecular Sequence Data

KW - RNA, Viral

KW - Sequence Analysis, DNA

KW - Viral Nonstructural Proteins

KW - Virulence Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1099/vir.0.047175-0

DO - 10.1099/vir.0.047175-0

M3 - Journal article

C2 - 23100370

VL - 94

SP - 263

EP - 269

JO - Journal of General Virology

JF - Journal of General Virology

SN - 0022-1317

IS - 2

ER -