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Increased serum PCSK9 levels are associated with renal function impairment in patients with type 2 diabetes mellitus

Dataset

  • Zhicai Feng (Creator)
  • Xiangyu Liao (Creator)
  • Hao ZhangRuian People's Hospital, Zhejiang Univ, Zhejiang University, Inst Informat & Commun Engn, Fudan Univ, Fudan University, Sch Informat Sci & Technol, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China., First Affiliated Hospital of Harbin Medical University, Jilin University, Chinese Academy of Medical Sciences & Peking Union Medical College, Changhai Hospital, Nanyang Technol Univ, Nanyang Technological University, Nanyang Technological University & National Institute of Education (NIE) Singapore, Sch Mat Sci & Engn, Dalian University of Technology, Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Arthritis Research Canada Vancouver British Columbia Canada; Department of Rehabilitation Medicine, West China Hospital Sichuan University Chengdu Sichuan China; Rehabilitation Medicine Key Laboratory of Sichuan Province, West China Hospital Sichuan University Chengdu Sichuan China, Jinan Univ, Jinan University, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Ocean University of China, Guangdong University of Petrochemical Technology, Guangzhou & Chinese Academy of Sciences, Shanghai Jiao Tong Univ, Shanghai Jiao Tong University, Sch Mech Engn, Zhongnan Hospital of Wuhan University, Shanghai Stomatological Hospital, Chongqing Medical University, Nanjing Medical University, Henan Normal University, Jiangnan University, Huazhong University of Science and Technology, Harvard Univ, Harvard University, Dept Phys, Heilongjiang Provincial Hospital, Univ Chinese Acad Sci, Chinese Academy of Sciences, University of Chinese Academy of Sciences, CAS, McGill Univ, McGill University, McGill Sch Environm, South China University of Technology, Cornell Univ, Cornell University, Kavli Inst Cornell, Second Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Second Affiliated Hospital of Harbin Medical University, Shandong University, Qingdao, Shandong 266237, China, Univ Arizona, University of Arizona, Northwestern Polytechnical University Xian, Yunnan Academy of Agricultural Sciences, Guangdong Pharmaceutical University, Hubei Academy of Agricultural Sciences, Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China, Urology Department The Affiliated Qingdao Central Hospital of Qingdao University, The Second Affiliated Hospital of Medical College of Qingdao University Qingdao Shandong China, The First Affiliated Hospital, Dalian Medical University, Dalian, China, Univ Victoria, University of Victoria, Dept Phys & Astron, Shanghai Children's Medical Center, Nanchang University (Creator)
  • Juan Peng (Creator)
  • Zhijun Huang (Creator)
  • Buqing Yi (Creator)

Description

The purpose of this study was to investigate the association between serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and renal function impairment in type 2 diabetes mellitus (T2DM) patients. PCSK9 levels were measured in T2DM patients, streptozotocin plus high-fat diet (STZ + HFD) mice, human proximal tubular epithelial (HK-2) cells treated with high glucose plus palmitic acid (HGPA) and the corresponding control groups. The T2DM patients were further divided into three groups according to serum PCSK9 levels. An analysis of clinical data was conducted, and a binary logistic regression model was used to test the relationship between potential predictors and urine albumin/urine creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR). PCSK9 levels were higher in the DM group than in the control group in humans, mice and HK-2 cells. The systolic blood pressure (SBP), serum creatinine (Scr), blood urea nitrogen (BUN), triglyceride (TG), and urine α1-MG/urine creatinine ratio (UαCR) values in PCSK9 tertile 3 were significantly higher than those in PCSK9 tertile 1 (p < 0.05). The DBP and UACR values were significantly higher in PCSK9 tertile 3 than in PCSK9 tertile 1 and PCSK9 tertile 2 (both p < 0.05). In addition, URCR values were significantly higher in PCSK9 tertile 3 and PCSK9 tertile 2 than in PCSK9 tertile 1 (both p < 0.05). Serum PCSK9 levels were positively correlated with SBP, Scr, BUN, TG, URCR, UαCR and UACR but inversely correlated with eGFR. In STZ + HFD mice, serum PCSK9 levels were positively correlated with Scr, BUN and UACR, which was consistent with the findings in the patients. A logistic regression model revealed that serum PCSK9 is an independent risk factor for UACR ≥30 mg/g and eGFR
Date made available2023
PublisherTaylor & Francis

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