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SNTB1 regulates colorectal cancer cell proliferation and metastasis through YAP1 and the WNT/β-catenin pathway

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  • Hao ZhangZhejiang University, University of Victoria, Shanghai Children's Medical Center, Department of Pathology, The First Affiliated Hospital of Hainan Medical University, Haikou, China;, Cornell University, First Affiliated Hospital of Harbin Medical University, Jiangsu Province Hospital, Sichuan University, Guangdong Pharmaceutical University, McGill University, Nanjing Agricultural University, Beijing Anzhen Hospital, Ruijin Hospital, Northwestern Polytechnical University Xian, China agricultural University, Nanchang University, Jinan University, Guangdong University of Petrochemical Technology, Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Hubei Academy of Agricultural Sciences, Zhongnan Hospital of Wuhan University, University of Arizona, Second Affiliated Hospital of Nanjing Medical University, Yunnan Academy of Agricultural Sciences, Ruian People's Hospital, Fudan University, Huazhong University of Science and Technology, Harvard University, Jiangnan University, Second Affiliated Hospital of Harbin Medical University, Shanghai Jiao Tong University, Wenzhou Medical University, Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China, Changhai Hospital, South China University of Technology, Nanjing Medical University, Henan Normal University, Chongqing Medical University, Jilin University, University of Chinese Academy of Sciences, Heilongjiang Provincial Hospital, Dalian University of Technology, Chinese Academy of Medical Sciences & Peking Union Medical College, Shanghai Stomatological Hospital, Chinese Academy of Sciences, Shandong University, Urology Department The Affiliated Qingdao Central Hospital of Qingdao University, The Second Affiliated Hospital of Medical College of Qingdao University Qingdao Shandong China, Ocean University of China, Hunan Agricultural University, Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Nanyang Technological University (Creator)
  • Zheng Li (Creator)
  • Juan Jiang (Creator)
  • Yang Lei (Creator)
  • Jingmao Xie (Creator)
  • Yihui Liu (Creator)
  • Bo Yi (Creator)

Description

Colorectal cancer is a common type of digestive tract cancer with a significant morbidity and death rate across the world, partially attributing to the metastasis-associated problems. In this study, integrative bioinformatics analyses were performed to identify genes that might contribute to colorectal cancer metastasis, and 293 genes were dramatically increased and 369 genes were decreased within colon cancer samples. Among up-regulated genes, top five genes correlated with colorectal cancer patient’s prognosis were verified for expression in clinical samples and syntrophin beta 1 (SNTB1) was the most up-regulated. In vitro, SNTB1 knockdown suppresses the malignant behaviors of colorectal cancer cells, including cell viability, colony formation capacity, as well as the abilities to migrate and invade. Furthermore, SNTB1 knockdown decreased the levels of Wnt1, C-Jun, C-Myc, TCF7, and cyclin D1, and inhibited EMT in both cell lines. In vivo, SNTB1 knockdown inhibited tumor growth and metastasis in nude mice models. SNTB1 positively regulated Yes1 associated transcriptional regulator (YAP1) expression; YAP1 partially reversed the effects of SNTB1 on colorectal cancer cell phenotypes and the Wnt/β-catenin/MYC signaling. In conclusion, SNTB1 knockdown inhibits colorectal cancer cell aggressiveness in vitro and tumor growth and metastasis in vivo through the Wnt/β-catenin/MYC signaling; YAP1 might mediate SNTB1 functions on colorectal cancer.
Date made available2023
PublisherTaylor & Francis

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