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Value of the HFA-PEFF diagnostic algorithms for heart failure with preserved ejection fraction to the inflammatory myopathy population

Dataset

  • Yunjing Shi (Creator)
  • Hao ZhangChongqing Medical University, Department of Pathology, The First Affiliated Hospital of Hainan Medical University, Haikou, China;, Jiangnan University, Ruian People's Hospital, China agricultural University, Guangdong Pharmaceutical University, Yunnan Academy of Agricultural Sciences, Wenzhou Medical University, Nanjing Agricultural University, Cornell University, First Affiliated Hospital of Harbin Medical University, Jiangsu Province Hospital, Jilin University, Nanchang University, Heilongjiang Provincial Hospital, Changhai Hospital, Huazhong University of Science and Technology, Zhongnan Hospital of Wuhan University, Urology Department The Affiliated Qingdao Central Hospital of Qingdao University, The Second Affiliated Hospital of Medical College of Qingdao University Qingdao Shandong China, Shandong University, Chinese Academy of Sciences, Hubei Academy of Agricultural Sciences, Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China, Nanyang Technological University, Second Affiliated Hospital of Harbin Medical University, Sichuan University, Second Affiliated Hospital of Nanjing Medical University, Ruijin Hospital, Ocean University of China, Shanghai Children's Medical Center, Nanjing Medical University, Guangdong University of Petrochemical Technology, Northwestern Polytechnical University Xian, Chinese Academy of Medical Sciences & Peking Union Medical College, South China University of Technology, Beijing Anzhen Hospital, Dalian University of Technology, Zhejiang University, Henan Normal University, University of Arizona, University of Victoria, University of Chinese Academy of Sciences, Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Shanghai Jiao Tong University, Jinan University, McGill University, Harvard University, Fudan University, Shanghai Stomatological Hospital, Hunan Agricultural University (Creator)
  • Zeping Qiu (Creator)
  • Yanjia Chen (Creator)
  • Xiuxiu Su (Creator)
  • Huihui Chi (Creator)
  • Tienan Feng (Creator)
  • Yue Sun (Creator)
  • Honglei Liu (Creator)
  • Xiaobing Cheng (Creator)
  • Junna Ye (Creator)
  • Hui Shi (Creator)
  • Qiongyi Hu (Creator)
  • Zhuochao Zhou (Creator)
  • Jianfen Meng (Creator)
  • Jialin Teng (Creator)
  • Chengde Yang (Creator)
  • Yutong Su (Creator)
  • Wei Jin (Creator)

Description

Abstract Objectives The HFA-PEFF score has been validated to hold great diagnostic and prognostic utility for heart failure with preserved ejection fraction (HFpEF). Idiopathic inflammatory myopathy (IIM) is recognized as one of the potential etiologies underlying HFpEF. Here, we intended to investigate the real prevalence of HFpEF in IIM via the HFA-PEFF score and explore the prognostic value of this score. Methods Two hundred twenty IIM patients were enrolled for assessment. The cohort was divided into low, intermediate and high tertiles of the HFA-PEFF score. Spearman’s correlation analysis was used to explore the association between the score and disease activity. Chi-square test was applied to investigate the distribution discrepancy of HFA-PEFF tertiles among patients with different myositis-specific antibodies (MSAs) or myositis-associated antibodies (MAAs). Univariate and multivariate ordinal regression analyses were performed to screen risk factors for high HFA-PEFF scores. Survival curves were obtained using the Kaplan–Meier method and log-rank tests. Results In total, 79 (35.9%), 107 (48.6%) and 34 (15.5%) patients were rated low, intermediate and high probability of HFpEF, respectively. The HFA-PEFF score correlated well with disease activity. Patients with positive AMA-M2 scored higher in the HFA-PEFF score (p = 0.011). During follow-up, patients with positive AMA-M2 or anti-SRP antibody developed an inclination towards concentric hypertrophy on echocardiography. Additionally, palpitation symptom, AMA-M2 positivity and elevated serum levels of LDH, cTnI were independent risk factors for high HFA-PEFF scores. Finally, a high-tertile HFA-PEFF score was related to lower overall survival rate (p < 0.001). Patients with positive AMA-M2 had poorer outcomes (p = 0.002). Conclusion HFpEF was prevailing in IIM patients according to the HFA-PEFF score. The HFA-PEFF score correlated well with disease activity and held significant prognostic value. Patients with AMA-M2 antibody were prone to have poor outcomes.
Date made available2023
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