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Professor Christian Holscher

Formerly at Lancaster University

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  1. Published

    抗糖尿病新药(D-Ser2)Oxm 拮抗淀粉样β 蛋白细胞毒性的神经保护 效应观察

    Han, Y-F., Hölscher, C., Wang, Z-J., Zhang, J., Yuan, L., Tong, J-Q., Wang, D-D., Wu, M-N. & Qi, J-S., 25/06/2016, In: Acta Physiologica Sinica. 68, 3, p. 265-275 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer’s disease as detected by GC-MS

    Nasaruddin, M. L., Holscher, C., Kehoe, P., Graham, S. F. & Green, B., 30/01/2016, In: American Journal of Translational Research. 8, 1, p. 154-165 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Val⁸-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats

    Wang, X-H., Yang, W., Hölscher, C., Wang, Z-J., Cai, H-Y., Li, Q-S. & Qi, J-S., 04/2013, In: Journal of Neuroscience Research. 91, 4, p. 568-577 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

    Gengler, S., McClean, P. L., McCurtin, R., Gault, V. A. & Holscher, C., 02/2012, In: Neurobiology of Aging. 33, 2, p. 265-276 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease

    Graham, S. F., Chevallier, O. P., Elliott, C. T., Holscher, C., Johnston, J., McGuinness, B., Kehoe, P. G., Passmore, A. P. & Green, B. D., 24/03/2015, In: PLoS ONE. 10, 3, 16 p., e0119452.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease

    Feng, P., Zhang, X., Li, D., Ji, C., Yuan, Z., Wang, R., Xue, G., Li, G. & Hölscher, C., 1/05/2018, In: Neuropharmacology. 133, p. 385-394 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-Amyloid oligomers in mice and monkeys

    Lourenco, M. V., Clarke, J. R., Frozza, R. L., Bomfim, T. R., Forny-Germano, L., Batista, A. F., Sathler, L. B., Brito-Moreira, J., Amaral, O. B., Silva, C. A., Freitas-Correa, L., Espírito-Santo, S., Campello-Costa, P., Houzel, J-C., Klein, W. L., Holscher, C., Carvalheira, J. B., Silva, A. M., Velloso, L. A., Munoz, D. P., & 2 othersFerreira, S. T. & De Felice, F. G., 3/12/2013, In: Cell Metabolism. 18, 6, p. 831-843 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Therapeutic potential of genipin in central neurodegenerative diseases

    Li, Y., Li, L. & Holscher, C., 10/2016, In: CNS Drugs. 30, 10, p. 889-897 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Therapeutic potential of flavonoids in spinal cord injury

    Zhang, P., Holscher, C. & Ma, X., 01/2017, In: Reviews in the Neurosciences. 28, 1, p. 87-101 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Therapeutic Potential of Baicalein in Alzheimer's Disease and Parkinson's Disease

    Li, Y., Zhao, J. & Holscher, C., 08/2017, In: CNS Drugs. 31, 8, p. 639-652 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain

    Parthsarathy, V. & Hölscher, C., 30/01/2013, In: European Journal of Pharmacology. 700, 1-3, p. 42-50 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    The role of GLP-1 in neuronal activity and neurodegeneration

    Hölscher, C., 2010, In: Vitamins and Hormones. 84, p. 331-354 24 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    The Novel DA-CH3 Dual Incretin Restores Endoplasmic Reticulum Stress and Autophagy Impairments to Attenuate Alzheimer-Like Pathology and Cognitive Decrements in the APPSWE/PS1ΔE9 Mouse Model

    Panagaki, T., Gengler, S. & Hölscher, C., 16/10/2018, In: Journal of Alzheimer's Disease. 66, 1, p. 195-218 24 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

    Hölscher, C., 02/2014, In: Alzheimer's and Dementia. 10, 1 Supplement, p. S47-54 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease

    Duffy, A. M. & Hölscher, C., 3/01/2013, In: Neuroscience. 228, p. 294-300 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    The effect of mGlu8 deficiency in animal models of psychiatric diseases

    Fendt, M., Bürki, H., Imobersteg, S., van der Putten, H., McAllister, K., Leslie, J. C., Shaw, D. & Hölscher, C., 02/2010, In: Genes, Brain and Behavior. 9, 1, p. 33-44 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease

    Hamilton, A. & Holscher, C., 17/04/2012, In: Brain Research. 1449, p. 83-93 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease

    McClean, P. L., Parthsarathy, V., Faivre, E. & Holscher, C., 27/04/2011, In: Journal of Neuroscience. 31, 17, p. 6587-6594 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease

    Long-Smith, C. M., Manning, S., McClean, P. L., Coakley, M. F., O'Halloran, D. J., Holscher, C. & O'Neill, C., 03/2013, In: NeuroMolecular Medicine. 15, 1, p. 102-114 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    Synaptic plasticity in the hippocampus of an APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice

    Gengler, S., Hamilton, A. & Holscher, C., 22/03/2010, In: PLoS ONE. 5, 3, 10 p., e9764.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide™

    Kelly, P., McClean, P. L., Ackermann, M., Konerding, M. A., Holscher, C. & Mitchell, C. A., 02/2015, In: Microcirculation. 22, 2, p. 133-145 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

    Hamilton, A. & Hölscher, C., 26/08/2009, In: NeuroReport. 20, 13, p. 1161-1166 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    Quantitative measurement of [Na+] and [K+] in postmortem human brain tissue indicates disturbances in subjects with Alzheimer's Disease and dementia with Lewy bodies

    Graham, S. F., Nasarauddin, M. B., Carey, M., McGuinness, B., Holscher, C., Kehoe, P. G., Love, S., Passmore, A. P., Elliott, C. T., Meharg, A. & Green, B. D., 2015, In: Journal of Alzheimer's Disease. 44, 3, p. 851-857 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice

    McClean, P. L., Jalewa, J. & Holscher, C., 15/10/2015, In: Behavioural Brain Research. 293, p. 96-106 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

    Porter, D. W., Irwin, N., Flatt, P. R., Hölscher, C. & Gault, V. A., 15/01/2011, In: European Journal of Pharmacology. 650, 2-3, p. 688-693 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. Published

    Prolonged Drug-Releasing Fibers Attenuate Alzheimer's Disease-like Pathogenesis

    Salles, G. N., Calió, M. L., Afewerki, S., Pacheco-Soares, C., Porcionatto, M., Hölscher, C. & Lobo, A. O., 31/10/2018, In: ACS Applied Materials and Interfaces. 10, 43, p. 36693-36702 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. Published

    Potential roles of glucagon-like peptide-1 (GLP-1) in neuroprotection

    Holscher, C., 10/2012, In: CNS Drugs. 26, 10, p. 871-882 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  28. Published

    Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus

    Wang, R-F., Xue, G-F., Hölscher, C., Tian, M-J., Feng, P., Zheng, J-Y. & Li, D-F., 05/2018, In: Epilepsy Research. 142, p. 45-52 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  29. Published

    Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology

    Olmos-Alonso, A., Schetters, S. T. T., Sri, S., Askew, K., Mancuso, R., Vargas-Caballero, M., Holscher, C., Perry, V. H. & Gomez-Nicola, D., 1/03/2016, In: Brain. 139, 3, p. 891-907 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  30. Published

    Pharmacological inhibition of CSF1R blocks microglial proliferation and prevents the progression of Alzheimer's-like pathology

    Olmos-Alonso, A., Schetters, S. T., Sri, S., Askew, K., Vargas-Caballero, M., Holscher, C., Perry, V. H. & Gomez-Nicola, D., 08/2015, In: Glia. 63, Suppl. 1, p. E346-E347 2 p.

    Research output: Contribution to Journal/Magazine › Meeting abstract › peer-review

  31. Published

    Peptide drugs that have been developed to treat type 2 diabetes show neuroprotective effects

    Holscher, C., 06/2014, In: Regulatory Peptides. 192-193, p. 55-56 2 p.

    Research output: Contribution to Journal/Magazine › Editorial › peer-review

  32. Published

    Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells

    Jalewa, J., Sharma, M. K. & Holscher, C., 10/2016, In: Journal of Neurochemistry. 139, 1, p. 55-67 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  33. Published

    Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

    Hamilton, A., Patterson, S., Porter, D., Gault, V. A. & Hölscher, C., 04/2011, In: Journal of Neuroscience Research. 89, 4, p. 481-489 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  34. Published

    Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

    Hölscher, C., 1/07/2018, In: Neuropharmacology. 136, Part B, p. 251-259 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  35. Published

    New animal models of Alzheimer's disease that display insulin desensitization in the brain

    Gao, C., Liu, Y., Li, L. & Hölscher, C., 12/2013, In: Reviews in the Neurosciences. 24, 6, p. 607-615 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  36. Published

    Neuroprotective role of (Val8)GLP-1-Glu-PAL in an in vitro model of Parkinson’s disease

    Li, L., Liu, K., Holscher, C., Li, G. & Liu, Y-Z., 2016, In: Neural Regeneration Research. 11, 2, p. 326-331 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  37. Published

    Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model

    Zhang, L., Zhang, L., Li, L. & Hölscher, C., 10/2018, In: Neuropeptides. 71, p. 70-80 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  38. Published

    Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

    Liu, W., Jalewa, J., Sharma, M., Li, G., Li, L. & Holscher, C., 10/09/2015, In: Neuroscience. 303, p. 42-50 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  39. Published

    Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease

    Ji, C., Xue, G-F., Li, G., Li, D. & Holscher, C., 01/2016, In: Reviews in the Neurosciences. 27, 1, p. 61-70 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  40. Published

    Neuroprotective effects of geniposide on Alzheimer's disease pathology

    Liu, W., Li, G., Holscher, C. & Li, L., 08/2015, In: Reviews in the Neurosciences. 26, 4, p. 371-383 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  41. Published

    Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease

    Chen, Y., Zhang, Y., Li, L. & Holscher, C., 5/12/2015, In: European Journal of Pharmacology. 768, p. 21-27 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  42. Published

    Neuroprotective effects of D-Ala2GIP on Alzheimer’s disease biomarkers in an APP/PS1 mouse model

    Faivre, E. & Holscher, C., 19/04/2013, In: Alzheimer's Research and Therapy. 5, p. 20-29 10 p., 20.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  43. Published

    Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease

    Liu, W., Li, Y., Jalewa, J., Saunders-Wood, T., Li, L. & Hölscher, C., 2015, In: European Journal of Pharmacology. 765, p. 284-290 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  44. Published

    Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease

    Tai, J., Liu, W., Li, Y., Li, L. & Hölscher, C., 1/01/2018, In: Brain Research. 1678, p. 64-74 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  45. Published

    Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

    Li, Y., Liu, W., Li, L. & Holscher, C., 02/2016, In: Neuropharmacology. 101, p. 255-263 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  46. Published

    Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson's disease mouse model

    Zhang, Y., Chen, Y., Li, L. & Holscher, C., 15/10/2015, In: Behavioural Brain Research. 293, p. 107-113 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  47. Published

    Neuroprotective and anti-apoptotic effects of Liraglutide on SH-SY5Y cells exposed to Methylglyoxal stress

    Sharma, M., Jalewa, J. & Hölscher, C., 02/2014, In: Journal of Neurochemistry. 128, 3, p. 459-471 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  48. Published

    Neural circuit interactions between the dorsal raphe nucleus and the lateral hypothalamus: an experimental and computational study

    Jalewa, J., Joshi, A., McGinnity, T. M., Prasad, G., Wong-Lin, K. & Hölscher, C., 6/02/2014, In: PLoS ONE. 9, 2, 16 p., e88003.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  49. Published

    Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue

    Graham, S. F., Holscher, C. & Green, B. D., 08/2014, In: Metabolomics. 10, 4, p. 744-753 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  50. Published

    Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

    McClean, P. L. & Holscher, C., 11/2014, In: Neuropharmacology. 86, p. 241-258 18 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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