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Professor David Middleton

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  1. Published

    Inhibitors of protein aggregation and toxicity

    Amijee, H., Madine, J., Middleton, D. A. & Doig, A. J., 08/2009, In: Biochemical Society Transactions. 37, Pt 4, p. 692-6 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    The dynamics and orientation of a lipophilic drug within model membranes determined by 13C solid-state NMR

    Boland, M. P. & Middleton, D. A., 7/01/2008, In: Physical Chemistry Chemical Physics. 10, 1, p. 178-85 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin

    Davies, H. A., Madine, J. & Middleton, D. A., 01/2012, In: June 2002. ISSN 1460-4582. 18, 1, p. 65-72 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Expression and purification of the aortic amyloid polypeptide medin

    Davies, H. A., Wilkinson, M. C., Gibson, R. P. & Middleton, D. A., 06/2014, In: Protein Expression and Purification. 98, p. 32-37 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Comparisons with amyloid-β reveal an aspartate residue that stabilizes fibrils of the aortic amyloid peptide medin

    Davies, H., Madine, J. & Middleton, D., 20/03/2015, In: Journal of Biological Chemistry. 290, p. 7791-7803 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Measurement of multiple torsional angles from one-dimensional solid-state NMR spectra: application to the conformational analysis of a ligand in its biological receptor site

    Edwards, R., Madine, J., Fielding, L. & Middleton, D. A., 14/11/2010, In: June 2002. ISSN 1460-4582. 12, 42, p. 13999-4008 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    A study of the membrane association and regulatory effect of the phospholemman cytoplasmic domain

    Hughes, E., Whittaker, C. A. P., Barsukov, I. L., Esmann, M. & Middleton, D. A., 04/2011, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808, 4, p. 1021-31 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Heparin-derived oligosaccharides interact with the phospholamban cytoplasmic domain and stimulate SERCA function

    Hughes, E., Edwards, R. & Middleton, D. A., 22/10/2010, In: Biochemical and Biophysical Research Communications. 401, 3, p. 370-5 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Cytoplasmic residues of phospholamban interact with membrane surfaces in the presence of SERCA: a new role for phospholipids in the regulation of cardiac calcium cycling?

    Hughes, E., Clayton, J. C. & Middleton, D. A., 02/2009, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788, 2, p. 559-66 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Comparison of the structure and function of phospholamban and the Arginine-14 deficient mutant associated with dilated cardiomyopathy

    Hughes, E. & Middleton, D. A., 16/09/2014, In: PLoS ONE. 9, 9, 10 p., 106746.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Average orientation of a fluoroaromatic molecule in lipid bilayers from DFT-informed NMR measurements of 1H-19F dipolar couplings

    Hughes, E., Griffin, J. M., Coogan, M. P. & Middleton, D. A., 21/07/2018, In: Physical Chemistry Chemical Physics. 20, 27, p. 18207-18215 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues

    Jack, E. R., Madine, J., Lian, L-Y. & Middleton, D. A., 01/2008, In: Molecular Membrane Biology. 25, 1, p. 14-22 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR

    Lau, S., Griffin, J., Hughes, E. & Middleton, D., 14/11/2019, In: Chemical Communications. 55, 88, p. 13287-13290 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    Sensitive morphological characterization of oriented high‐density lipoprotein nanoparticles using 31P NMR spectroscopy

    Lau, S. & Middleton, D., 5/10/2020, In: Angewandte Chemie International Edition. 59, 41, p. 18126-18130 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Forthcoming

    Analysis of the orientation of cholesterol in high-density lipoprotein nanodiscs using solid-state NMR

    Lau, S. & Middleton, D., 7/09/2022, (Accepted/In press) In: Physical Chemistry Chemical Physics.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    Site-specific identification of an aβ fibril-heparin interaction site by using solid-state NMR spectroscopy

    Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E. & Middleton, D. A., 21/12/2012, In: Angewandte Chemie International Edition. 51, 52, p. 13140-3 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

    Madine, J., Davies, H. A., Shaw, C., Hamley, I. W. & Middleton, D. A., 21/03/2012, In: Chemical Communications. 48, 24, p. 2976-8 3 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin

    Madine, J. & Middleton, D. A., 08/2010, In: June 2002. ISSN 1460-4582. 39, 9, p. 1281-8 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Evaluation of beta-alanine- and GABA-substituted peptides as inhibitors of disease-linked protein aggregation

    Madine, J., Wang, X., Brown, D. R. & Middleton, D. A., 17/08/2009, In: June 2002. ISSN 1460-4582. 10, 12, p. 1982-7 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    Exploiting a (13)C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils

    Madine, J., Clayton, J. C., Yates, E. A. & Middleton, D. A., 7/06/2009, In: Organic and Biomolecular Chemistry . 7, 11, p. 2414-20 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    Cross-beta spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fiber diffraction measurements

    Madine, J., Copland, A., Serpell, L. C. & Middleton, D. A., 14/04/2009, In: Biochemistry. 48, 14, p. 3089-99 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    The effects of alpha-synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy

    Madine, J., Hughes, E., Doig, A. J. & Middleton, D. A., 09/2008, In: Molecular Membrane Biology. 25, 6-7, p. 518-27 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction

    Madine, J., Jack, E., Stockley, P. G., Radford, S. E., Serpell, L. C. & Middleton, D. A., 12/11/2008, In: Journal of the American Chemical Society. 130, 45, p. 14990-5001 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR

    Madine, J., Doig, A. J. & Middleton, D. A., 25/06/2008, In: Journal of the American Chemical Society. 130, 25, p. 7873-81 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    Heparin promotes the rapid fibrillization of a peptide with low intrinsic amyloidogenicity

    Madine, J., Davies, H. A., Hughes, E. & Middleton, D. A., 17/12/2013, In: Biochemistry. 52, 50, p. 8984-8992 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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