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Professor David Middleton

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  1. 2014
  2. Published

    Expression and purification of the aortic amyloid polypeptide medin

    Davies, H. A., Wilkinson, M. C., Gibson, R. P. & Middleton, D. A., 06/2014, In: Protein Expression and Purification. 98, p. 32-37 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Structures, chemotaxonomic significance, cytotoxic and Na+, K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica

    Zhang, R.-R., Tian, H.-Y., Tan, Y.-F., Chung, T.-Y., Sun, X.-H., Xia, X., Ye, W.-C., Middleton, D. A., Fedosova, N., Esmann, M., Tzen, J. T. C. & Jiang, R.-W., 2014, In: Organic and Biomolecular Chemistry . 12, 44, p. 8919-8929 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. 2013
  5. Published

    Heparin promotes the rapid fibrillization of a peptide with low intrinsic amyloidogenicity

    Madine, J., Davies, H. A., Hughes, E. & Middleton, D. A., 17/12/2013, In: Biochemistry. 52, 50, p. 8984-8992 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid-State NMR Spectroscopic Measurements on an Aligned Sample

    Middleton, D. A., Madine, J., Castelletto, V. & Hamley, I. W., 27/09/2013, In: Angewandte Chemie International Edition. 52, 40, p. 10537-10540

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Probing the contacts of a low-affinity substrate with a membrane-embedded transport protein using 1H-13C cross-polarisation magic-angle spinning solid-state NMR

    Patching, S. G., Henderson, P. J. F., Sharples, D. J. & Middleton, D. A., 03/2013, In: Molecular Membrane Biology. 30, 2, p. 129-37 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. 2012
  9. Published

    Site-specific identification of an aβ fibril-heparin interaction site by using solid-state NMR spectroscopy

    Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E. & Middleton, D. A., 21/12/2012, In: Angewandte Chemie International Edition. 51, 52, p. 13140-3 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

    Madine, J., Davies, H. A., Shaw, C., Hamley, I. W. & Middleton, D. A., 21/03/2012, In: Chemical Communications. 48, 24, p. 2976-8 3 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Amyloid-derived peptide forms self-assembled monolayers on gold nanoparticle with a curvature-dependent β-sheet structure

    Shaw, C. P., Middleton, D. A., Volk, M. & Lévy, R., 28/02/2012, In: ACS Nano. 6, 2, p. 1416-26 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin

    Davies, H. A., Madine, J. & Middleton, D. A., 01/2012, In: June 2002. ISSN 1460-4582. 18, 1, p. 65-72 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. 2011
  14. Published

    The conformation of ATP within the Na,K-ATPase nucleotide site: a statistically constrained analysis of REDOR solid-state NMR data

    Middleton, D. A., Hughes, E. & Esmann, M., 25/07/2011, In: Angewandte Chemie International Edition. 50, 31, p. 7041-4 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    A study of the membrane association and regulatory effect of the phospholemman cytoplasmic domain

    Hughes, E., Whittaker, C. A. P., Barsukov, I. L., Esmann, M. & Middleton, D. A., 04/2011, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808, 4, p. 1021-31 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    Solid-state NMR detection of 14N-13C dipolar couplings between amino acid side groups provides constraints on amyloid fibril architecture

    Middleton, D. A., 02/2011, In: June 2002. ISSN 1460-4582. 49, 2, p. 65-9 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. 2010
  18. Published

    Measurement of multiple torsional angles from one-dimensional solid-state NMR spectra: application to the conformational analysis of a ligand in its biological receptor site

    Edwards, R., Madine, J., Fielding, L. & Middleton, D. A., 14/11/2010, In: June 2002. ISSN 1460-4582. 12, 42, p. 13999-4008 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Heparin-derived oligosaccharides interact with the phospholamban cytoplasmic domain and stimulate SERCA function

    Hughes, E., Edwards, R. & Middleton, D. A., 22/10/2010, In: Biochemical and Biophysical Research Communications. 401, 3, p. 370-5 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin

    Madine, J. & Middleton, D. A., 08/2010, In: June 2002. ISSN 1460-4582. 39, 9, p. 1281-8 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. 2009
  22. Published

    Evaluation of beta-alanine- and GABA-substituted peptides as inhibitors of disease-linked protein aggregation

    Madine, J., Wang, X., Brown, D. R. & Middleton, D. A., 17/08/2009, In: June 2002. ISSN 1460-4582. 10, 12, p. 1982-7 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    Inhibitors of protein aggregation and toxicity

    Amijee, H., Madine, J., Middleton, D. A. & Doig, A. J., 08/2009, In: Biochemical Society Transactions. 37, Pt 4, p. 692-6 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    Structural analysis of uniformly (13)C-labelled solids from selective angle measurements at rotational resonance

    Patching, S. G., Edwards, R. & Middleton, D. A., 08/2009, In: June 2002. ISSN 1460-4582. 199, 2, p. 242-6 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    Solid-state NMR studies of adenosine 5'-triphosphate freeze-trapped in the nucleotide site of Na,K-ATPase

    Middleton, D. A., Hughes, E., Fedosova, N. U. & Esmann, M., 20/07/2009, In: June 2002. ISSN 1460-4582. 10, 11, p. 1789-92 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. Published

    Exploiting a (13)C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils

    Madine, J., Clayton, J. C., Yates, E. A. & Middleton, D. A., 7/06/2009, In: Organic and Biomolecular Chemistry . 7, 11, p. 2414-20 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. Published

    Cross-beta spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fiber diffraction measurements

    Madine, J., Copland, A., Serpell, L. C. & Middleton, D. A., 14/04/2009, In: Biochemistry. 48, 14, p. 3089-99 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  28. Published

    Cytoplasmic residues of phospholamban interact with membrane surfaces in the presence of SERCA: a new role for phospholipids in the regulation of cardiac calcium cycling?

    Hughes, E., Clayton, J. C. & Middleton, D. A., 02/2009, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788, 2, p. 559-66 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  29. 2008
  30. Published

    Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction

    Madine, J., Jack, E., Stockley, P. G., Radford, S. E., Serpell, L. C. & Middleton, D. A., 12/11/2008, In: Journal of the American Chemical Society. 130, 45, p. 14990-5001 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  31. Published

    Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR

    Patching, S. G., Psakis, G., Baldwin, S. A., Baldwin, J., Henderson, P. J. F. & Middleton, D. A., 09/2008, In: Molecular Membrane Biology. 25, 6-7, p. 474-84 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  32. Published

    The effects of alpha-synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy

    Madine, J., Hughes, E., Doig, A. J. & Middleton, D. A., 09/2008, In: Molecular Membrane Biology. 25, 6-7, p. 518-27 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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