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Professor David Middleton

Professor

  1. 2009
  2. Published

    Exploiting a (13)C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils

    Madine, J., Clayton, J. C., Yates, E. A. & Middleton, D. A., 7/06/2009, In: Organic and Biomolecular Chemistry . 7, 11, p. 2414-20 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  3. Published

    Cross-beta spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fiber diffraction measurements

    Madine, J., Copland, A., Serpell, L. C. & Middleton, D. A., 14/04/2009, In: Biochemistry. 48, 14, p. 3089-99 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  4. Published

    Cytoplasmic residues of phospholamban interact with membrane surfaces in the presence of SERCA: a new role for phospholipids in the regulation of cardiac calcium cycling?

    Hughes, E., Clayton, J. C. & Middleton, D. A., 02/2009, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788, 2, p. 559-66 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  5. 2008
  6. Published

    Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction

    Madine, J., Jack, E., Stockley, P. G., Radford, S. E., Serpell, L. C. & Middleton, D. A., 12/11/2008, In: Journal of the American Chemical Society. 130, 45, p. 14990-5001 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  7. Published

    Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR

    Patching, S. G., Psakis, G., Baldwin, S. A., Baldwin, J., Henderson, P. J. F. & Middleton, D. A., 09/2008, In: Molecular Membrane Biology. 25, 6-7, p. 474-84 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  8. Published

    The effects of alpha-synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy

    Madine, J., Hughes, E., Doig, A. J. & Middleton, D. A., 09/2008, In: Molecular Membrane Biology. 25, 6-7, p. 518-27 10 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  9. Published

    Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR

    Madine, J., Doig, A. J. & Middleton, D. A., 25/06/2008, In: Journal of the American Chemical Society. 130, 25, p. 7873-81 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  10. Published

    Solid-state NMR spectroscopy detects interactions between tryptophan residues of the E. coli sugar transporter GalP and the alpha-anomer of the D-glucose substrate

    Patching, S. G., Henderson, P. J. F., Herbert, R. B. & Middleton, D. A., 30/01/2008, In: Journal of the American Chemical Society. 130, 4, p. 1236-44 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  11. Published

    The dynamics and orientation of a lipophilic drug within model membranes determined by 13C solid-state NMR

    Boland, M. P. & Middleton, D. A., 7/01/2008, In: Physical Chemistry Chemical Physics. 10, 1, p. 178-85 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  12. Published

    Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues

    Jack, E. R., Madine, J., Lian, L-Y. & Middleton, D. A., 01/2008, In: Molecular Membrane Biology. 25, 1, p. 14-22 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

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