IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

Almine, J. F., O'Hare, C. A. J., Dunphy, G., Haga, I. R., Naik, R. J., Atrih, A., Connolly, D. J., Taylor, J., Kelsall, I. R., Bowie, A. G., Beard, P. M. & Unterholzner, L., 13/02/2017, In: Nature Communications. 8, 14392.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

The interferon response to intracellular DNA: why so many receptors?

Unterholzner, L., 11/2013, In: Immunobiology. 218, 11, p. 1312-1321 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

Horan, K. A., Hansen, K., Jakobsen, M. R., Holm, C. K., Søby, S., Unterholzner, L., Thompson, M., West, J. A., Iversen, M. B., Rasmussen, S. B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A. G., Fitzgerald, K. A. & Paludan, S. R., 1/03/2013, In: Journal of Immunology. 190, 5, p. 2311-2319 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

Mansur, D. S., Maluquer de Motes, C., Unterholzner, L., Sumner, R. P., Ferguson, B. J., Ren, H., Strnadova, P., Bowie, A. G. & Smith, G. L., 02/2013, In: PLoS Pathogens. 9, 2, e1003183.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor

Jin, T., Perry, A., Jiang, J., Smith, P., Curry, J. A., Unterholzner, L., Jiang, Z., Horvath, G., Rathinam, V. A., Johnstone, R. W., Hornung, V., Latz, E., Bowie, A. G., Fitzgerald, K. A. & Xiao, T. S., 20/04/2012, In: Immunity. 36, 4, p. 561-571 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7

Unterholzner, L., Sumner, R. P., Baran, M., Ren, H., Mansur, D. S., Bourke, N. M., Randow, F., Smith, G. L. & Bowie, A. G., 09/2011, In: PLoS Pathogens. 7, 9, e1002247.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Innate DNA sensing moves to the nucleus

Unterholzner, L. & Bowie, A. G., 19/05/2011, In: Cell Host and Microbe. 9, 5, p. 351-353 3 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

IFI16 is an innate immune sensor for intracellular DNA

Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., Fitzgerald, K. A., Paludan, S. R. & Bowie, A. G., 11/2010, In: Nature Immunology. 11, 11, p. 997-1004 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Viral evasion and subversion of pattern-recognition receptor signalling

Bowie, A. G. & Unterholzner, L., 12/2008, In: Nature Immunology. 8, 12, p. 911-922 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

The interplay between viruses and innate immune signaling: recent insights and therapeutic opportunities

Unterholzner, L. & Bowie, A. G., 1/02/2008, In: Biochemical Pharmacology. 75, 3, p. 589-602 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review