Investigation of IFI16 modulating molecules on Type I IFN inflammatory mediators following cytosolic DNA sensing or detection of nuclear DNA damage

Unterholzner, L. (Principal Investigator)

Kymera Therapeutics

1/10/23 → 31/03/24

Project: Research

Epithelial cells as sentinels in innate immunity

Unterholzner, L. (Principal Investigator)

The Royal Society

1/10/23 → 30/09/24

Project: Research

Talent and Research Stabilisation Fund 2022 (Leonie Unterholzner)

Unterholzner, L. (Principal Investigator)

21/11/22 → 31/03/23

Project: Research

Regulation of DNA repair and the innate immune response to radio- and chemotherapy by the DNA sensors cGAS and IFI16.

Unterholzner, L. (Principal Investigator)

North West Cancer Research Fund

1/10/23 → 30/09/26

Project: Research

STING signalling as link between DNA damaging therapies and innate immunity in bladder cancer

Unterholzner, L. (Principal Investigator)

Cancer Research UK Manchester Institute

1/12/22 → 30/11/25

Project: Research

3 Year Research PhD Studentship: Modulation of the innate immune responses by DNAzymes

Unterholzner, L. (Principal Investigator)

Defence Science and Technology Laboratory (DSTL)

4/01/21 → 30/04/24

Project: Research

How is the immune system alerted to persistent replication stress and DNA damage in keratinocytes during immunosurveillance against cutaneous squamous cell carcinoma?

Jackson-Jones, L. (Principal Investigator) & Unterholzner, L. (Co-Investigator)

North West Cancer Research Fund

1/10/19 → 30/09/24

Project: Research

The role of innate immunity in the response to radiation-induced DNA damage in human skin cells

Unterholzner, L. (Principal Investigator) & Allinson, S. (Co-Investigator)

North West Cancer Research Fund

1/02/19 → 30/04/19

Project: Research

Innate immune recognition of intracellular DNA as 'stranger' and 'danger' signal

Unterholzner, L. (Principal Investigator)

European Commission

1/01/15 → 31/12/18

Project: Research

NWCR Equipment bid: Faxitron CellRad Irradiator

Allinson, S. (Principal Investigator) & Unterholzner, L. (Co-Investigator)

North West Cancer Research Fund

1/10/18 → 31/03/19

Project: Research

Innate immune recognition of Herpes SImplex Virus in skin cells: Differences between neonatal and adult keratinocytes.

Unterholzner, L. (Principal Investigator)

1/08/14 → 28/02/16

Project: Research

How do keratinocytes sense the presence of intracellular DNA?

Unterholzner, L. (Principal Investigator)

1/02/14 → 31/08/15

Project: Research

IFNDNA: Elucidating the molecular mechanism of intracellular DNA recognition by the innate immune sensor IFI16

Unterholzner, L. (Principal Investigator)

1/02/13 → 31/07/18

Project: Research

How does p53 link DNA damage to innate immunity?

Unterholzner, L. (Principal Investigator)

North West Cancer Research Fund

1/01/18 → 31/05/21

Project: Research